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PMID: 12756226 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Transient activation of beta -catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice.

Genes & development ·Vol. 17 ·No. 10 ·2003-05-15 ·Pages 1219-24

Van Mater D, Kolligs FT, Dlugosz AA, Fearon ER

Abstract

Wnts have key roles in many developmental processes, including hair follicle growth and differentiation. Stabilization of beta-catenin is essential in the canonical Wnt signaling pathway. We developed transgenic mice expressing a regulated form of beta-catenin in the skin. Chronic activation of beta-catenin in resting (telogen) hair follicles resulted in changes consistent with induction of an exaggerated, aberrant growth phase (anagen). Transient activation of beta-catenin produced a normal anagen. Our data lend strong support to the notion that a Wnt/beta-catenin signal operating on hair follicle precursor cells serves as a crucial proximal signal for the telogen-anagen transition.

MeSH Terms

Animals Cell Differentiation/physiology Cytoskeletal Proteins/genetics,metabolism Epithelium/growth & development,physiology Hair/growth & development Hair Follicle/growth & development,physiology Keratinocytes/metabolism Mice Mice, Transgenic Signal Transduction Trans-Activators/genetics,metabolism beta Catenin

Chemicals

CTNNB1 protein, mouse Cytoskeletal Proteins Trans-Activators beta Catenin

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Van Mater David

Departments of Human Genetics, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA.

Kolligs Frank T

Dlugosz Andrzej A

Fearon Eric R

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Article Info

Journal

Genes & development

Abbr.

Genes Dev

ISSN

0890-9369

DOI

10.1101/gad.1076103

Published

2003-05-15

Pages

1219-24

Language

English

Region

United States

NLM ID

8711660

PMCID

PMC196062

Subset

Grants

NIGMS NIH HHS · T32GM07863 · United States

NCI NIH HHS · P30 CA046592 · United States

NCI NIH HHS · R01 CA085463 · United States

NIGMS NIH HHS · T32 GM007863 · United States

NCI NIH HHS · CA46592 · United States

NIAMS NIH HHS · R01 AR045973 · United States

NCI NIH HHS · R01 CA087837 · United States

NCI NIH HHS · CA85463 · United States

NCI NIH HHS · CA87837 · United States

External Links

PubMed source DOI: 10.1101/gad.1076103 PMC Full Text View journal details

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Transient activation of beta -catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice.

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