Abstract
The end products of the metabolism of phenylalanine, tyrosine and tryptophan by growing cultures of clostridia have been identified. The species used were Clostridium aminovalericum; C. bifermentans; C. botulinum proteolytic type A; C. botulinum proteolytic type B; C. cochlearium; C. difficile; C. ghoni; C. histolyticum; C. lentoputrescens; C. limosum; C. lituseburense; C. malenomenatum; C. mangenoti; C. propionicum; C. putrefaciens; C. sordellii; C. sporogenes; C. sporosphaeroides; C. sticklandii; C. subterminale; C. tetani; C. tetanomorphum. The mixture of aromatic compounds formed, which depended upon the species, included phenyl acetic acid, phenyl propionic acid, phenyl lactic acid, phenol, p-cresol, p-hydroxy phenyl acetic acid, p-hydroxy phenyl propionic acid, indole, indole acetic acid and indole propionic acid.
MeSH Terms
Amino Acids/metabolism
Clostridium/metabolism
Indoleacetic Acids/metabolism
Indoles/metabolism
Phenols/metabolism
Phenylacetates/metabolism
Phenylalanine/metabolism
Tryptophan/metabolism
Tyrosine/metabolism
Chemicals
Amino Acids
Indoleacetic Acids
Indoles
Phenols
Phenylacetates
Tyrosine
Phenylalanine
Tryptophan
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Elsden S R
Hilton M G
Waller J M
References (20)
20 references, click to expand
-
The metabolism of pyrimidines by proteolytic clostridia.
Arch Microbiol. 1975;102(2):145-9
PMID: 235246
-
Conversion of L-tyrosine to phenol by Clostridium tetanomorphum.
Arch Biochem Biophys. 1965 Oct;112(1):1-6
PMID: 5865116
-
The metabolism of aromatic compounds in higher plants. IV. Purification and properties of the phenylalanine deaminase of Hordeum vulgare.
J Biol Chem. 1961 Oct;236:2692-8
PMID: 14458851
-
A press for disrupting bacteria and other micro-organisms.
Br J Exp Pathol. 1951 Apr;32(2):97-109
PMID: 14848424
-
Indolelactate dehydrogenase from Clostridium sporogenes.
Can J Microbiol. 1968 Apr;14(4):429-35
PMID: 4384683
-
Studies in the metabolism of the strict anaerobes (genus Clostridium): Hydrogen production and amino-acid utilization by Clostridium tetanomorphum.
Biochem J. 1937 Oct;31(10):1774-88
PMID: 16746517
-
The photometabolism of propionate by Rhodospirillum rubrum.
Biochem J. 1962 Jul;84:170-85
PMID: 14457247
-
Production of hydrocinnamic acid by clostridia.
Appl Microbiol. 1970 Feb;19(2):375-8
PMID: 5437307
-
Two pathways of glutamate fermentation by anaerobic bacteria.
J Bacteriol. 1974 Mar;117(3):1248-60
PMID: 4813895
-
Fermentation of tyrosine by marine bacteria.
Arch Biochem. 1949 Mar;21(1):217-23
PMID: 18113506
-
Taxonomy of the Clostridia: ribosomal ribonucleic acid homologies among the species.
J Gen Microbiol. 1975 Jun;88(2):229-44
PMID: 168308
-
Correlation of toxic and non-toxic strains of Clostridium botulinum by DNA composition and homology.
J Gen Microbiol. 1970 Jan;60(1):117-23
PMID: 4922761
-
Tryptophan transaminase from Clostridium sporogenes.
Arch Biochem Biophys. 1968 Sep 20;127(1):361-9
PMID: 5697992
-
Tyrosine phenol lyase. I. Purification, crystallization, and properties.
J Biol Chem. 1970 Apr 10;245(7):1767-72
PMID: 4908868
-
The Stickland reaction.
Bacteriol Rev. 1954 Mar;18(1):16-42
PMID: 13140081
-
Studies of the metabolism of the strict anaerobes (genus: Clostridium): Dehydrogenation reactions by suspensions of Cl. sporogenes.
Biochem J. 1938 Mar;32(3):437-48
PMID: 16746637
-
Studies in the metabolism of the strict anaerobes (genus Clostridium): The chemical reactions by which Cl. sporogenes obtains its energy.
Biochem J. 1934;28(5):1746-59
PMID: 16745572
-
Metabolism of the strict anaerobes (genus: Clostridium): Reduction of amino-acids with gaseous hydrogen by suspensions of Cl. sporogenes.
Biochem J. 1938 Jun;32(6):949-57
PMID: 16746719
-
The amino acid-fermenting clostridia.
J Gen Microbiol. 1971 Jul;67(1):47-56
PMID: 5124513
-
Dissimilation of tryptophan and related indolic compounds by ruminal microorganisms in vitro.
Appl Microbiol. 1974 Mar;27(3):540-8
PMID: 4545142