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PMID: 12759232 Published · ppublish English Lecture Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Rous-Whipple Award Lecture. How tumors make bad blood vessels and stroma.

The American journal of pathology ·Vol. 162 ·No. 6 ·2003-06-00 ·Pages 1747-57

Dvorak HF

Abstract

暂无摘要

MeSH Terms
Animals Cytoplasmic Vesicles/pathology Endothelial Growth Factors/metabolism Endothelium, Vascular/metabolism,pathology,ultrastructure Humans Intercellular Signaling Peptides and Proteins/metabolism Lymphokines/metabolism Microscopy, Electron Neoplasms/blood supply,metabolism,pathology Neovascularization, Pathologic/pathology Vacuoles/pathology,ultrastructure Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors
Chemicals
Endothelial Growth Factors Intercellular Signaling Peptides and Proteins Lymphokines Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Dvorak Harold F
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA. [email protected]
References (48)
48 references, click to expand
  1. Glomeruloid microvascular proliferation follows adenoviral vascular permeability factor/vascular endothelial growth factor-164 gene delivery.
    Am J Pathol. 2001 Mar;158(3):1145-60 PMID: 11238063
  2. Neuropilin-1 expression by tumor cells promotes tumor angiogenesis and progression.
    FASEB J. 2000 Dec;14(15):2532-9 PMID: 11099472
  3. Contribution of marrow-derived progenitors to vascular and cardiac regeneration.
    Semin Cell Dev Biol. 2002 Feb;13(1):61-7 PMID: 11969372
  4. Ultrastructural studies define soluble macromolecular, particulate, and cellular transendothelial cell pathways in venules, lymphatic vessels, and tumor-associated microvessels in man and animals.
    Microsc Res Tech. 2002 Jun 1;57(5):289-326 PMID: 12112440
  5. Vascular permeability factor/vascular endothelial growth factor induces lymphangiogenesis as well as angiogenesis.
    J Exp Med. 2002 Dec 2;196(11):1497-506 PMID: 12461084
  6. VEGF-A induces angiogenesis, arteriogenesis, lymphangiogenesis, and vascular malformations.
    Cold Spring Harb Symp Quant Biol. 2002;67:227-37 PMID: 12858545
  7. Lymphatic vessels of the mammalian heart.
    Anat Rec. 1978 Jun;191(2):183-201 PMID: 666017
  8. Induction of a fibrin-gel investment: an early event in line 10 hepatocarcinoma growth mediated by tumor-secreted products.
    J Immunol. 1979 Jan;122(1):166-74 PMID: 762415
  9. Fibrin gel investment associated with line 1 and line 10 solid tumor growth, angiogenesis, and fibroplasia in guinea pigs. Role of cellular immunity, myofibroblasts, microvascular damage, and infarction in line 1 tumor regression.
    J Natl Cancer Inst. 1979 Jun;62(6):1459-72 PMID: 286118
  10. Tumor shedding and coagulation.
    Science. 1981 May 22;212(4497):923-4 PMID: 7195067
  11. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid.
    Science. 1983 Feb 25;219(4587):983-5 PMID: 6823562
  12. Quantitation of fibrinogen influx and fibrin deposition and turnover in line 1 and line 10 guinea pig carcinomas.
    Cancer Res. 1984 Aug;44(8):3348-54 PMID: 6744268
  13. Pathogenesis of desmoplasia. I. Immunofluorescence identification and localization of some structural proteins of line 1 and line 10 guinea pig tumors and of healing wounds.
    J Natl Cancer Inst. 1984 Nov;73(5):1195-205 PMID: 6387242
  14. Regulation of extravascular coagulation by microvascular permeability.
    Science. 1985 Mar 1;227(4690):1059-61 PMID: 3975602
  15. Tumor angiogenesis.
    Adv Cancer Res. 1985;43:175-203 PMID: 2581424
  16. A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines.
    Cancer Res. 1986 Nov;46(11):5629-32 PMID: 3756910
  17. Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing.
    N Engl J Med. 1986 Dec 25;315(26):1650-9 PMID: 3537791
  18. Fibrin containing gels induce angiogenesis. Implications for tumor stroma generation and wound healing.
    Lab Invest. 1987 Dec;57(6):673-86 PMID: 2447383
  19. Dynamic compliance of single perfused frog mesenteric capillaries and rat venules: a filtration coefficient correction.
    Int J Microcirc Clin Exp. 1989 Feb;8(1):43-52 PMID: 2722410
  20. Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis.
    J Clin Invest. 1989 Nov;84(5):1470-8 PMID: 2478587
  21. Vascular endothelial growth factor is a secreted angiogenic mitogen.
    Science. 1989 Dec 8;246(4935):1306-9 PMID: 2479986
  22. Vascular permeability factor, an endothelial cell mitogen related to PDGF.
    Science. 1989 Dec 8;246(4935):1309-12 PMID: 2479987
  23. Structure of solid tumors and their vasculature: implications for therapy with monoclonal antibodies.
    Cancer Cells. 1991 Mar;3(3):77-85 PMID: 1711364
  24. Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing.
    J Exp Med. 1992 Nov 1;176(5):1375-9 PMID: 1402682
  25. Pathways of macromolecular tracer transport across venules and small veins. Structural basis for the hyperpermeability of tumor blood vessels.
    Lab Invest. 1992 Nov;67(5):596-607 PMID: 1279271
  26. Fibroblast migration in fibrin gel matrices.
    Am J Pathol. 1993 Jan;142(1):273-83 PMID: 8424460
  27. Pathogenesis of ascites tumor growth: angiogenesis, vascular remodeling, and stroma formation in the peritoneal lining.
    Cancer Res. 1995 Jan 15;55(2):376-85 PMID: 7529135
  28. The vesiculo-vacuolar organelle (VVO): a distinct endothelial cell structure that provides a transcellular pathway for macromolecular extravasation.
    J Leukoc Biol. 1996 Jan;59(1):100-15 PMID: 8558058
  29. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele.
    Nature. 1996 Apr 4;380(6573):435-9 PMID: 8602241
  30. Vesiculo-vacuolar organelles and the regulation of venule permeability to macromolecules by vascular permeability factor, histamine, and serotonin.
    J Exp Med. 1996 May 1;183(5):1981-6 PMID: 8642308
  31. Vascular permeability factor/vascular endothelial growth factor: a multifunctional angiogenic cytokine.
    EXS. 1997;79:233-69 PMID: 9002222
  32. Vascular endothelial growth factor: basic biology and clinical implications.
    EXS. 1997;79:209-32 PMID: 9002234
  33. Isolation of putative progenitor endothelial cells for angiogenesis.
    Science. 1997 Feb 14;275(5302):964-7 PMID: 9020076
  34. Vascular development: cellular and molecular regulation.
    FASEB J. 1997 Apr;11(5):365-73 PMID: 9141503
  35. Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) delays and induces escape from senescence in human dermal microvascular endothelial cells.
    Oncogene. 1997 May 1;14(17):2025-32 PMID: 9160882
  36. VEGF and VEGF-C: specific induction of angiogenesis and lymphangiogenesis in the differentiated avian chorioallantoic membrane.
    Dev Biol. 1997 Aug 1;188(1):96-109 PMID: 9245515
  37. Vascular permeability factor/vascular endothelial growth factor and the significance of microvascular hyperpermeability in angiogenesis.
    Curr Top Microbiol Immunol. 1999;237:97-132 PMID: 9893348
  38. Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal.
    J Clin Invest. 1999 Jan;103(2):159-65 PMID: 9916127
  39. Pathways of macromolecular extravasation across microvascular endothelium in response to VPF/VEGF and other vasoactive mediators.
    Microcirculation. 1999 Mar;6(1):23-44 PMID: 10100187
  40. Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188.
    Nat Med. 1999 May;5(5):495-502 PMID: 10229225
  41. VEGFs, receptors and angiogenesis.
    Semin Cancer Biol. 1999 Jun;9(3):211-20 PMID: 10343072
  42. Gene therapy for myocardial angiogenesis.
    Am Heart J. 1999 Aug;138(2 Pt 2):S132-41 PMID: 10426872
  43. Different pathways of macromolecule extravasation from hyperpermeable tumor vessels.
    Microvasc Res. 2000 Jan;59(1):24-37 PMID: 10625568
  44. Heterogeneity of the angiogenic response induced in different normal adult tissues by vascular permeability factor/vascular endothelial growth factor.
    Lab Invest. 2000 Jan;80(1):99-115 PMID: 10653008
  45. Ultrastructural localization of the vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) receptor-2 (FLK-1, KDR) in normal mouse kidney and in the hyperpermeable vessels induced by VPF/VEGF-expressing tumors and adenoviral vectors.
    J Histochem Cytochem. 2000 Apr;48(4):545-56 PMID: 10727296
  46. Mechanisms of angiogenesis and arteriogenesis.
    Nat Med. 2000 Apr;6(4):389-95 PMID: 10742145
  47. Vascular-specific growth factors and blood vessel formation.
    Nature. 2000 Sep 14;407(6801):242-8 PMID: 11001067
  48. Intratumoral lymphatic vessels: a case of mistaken identity or malfunction?
    J Natl Cancer Inst. 2002 Mar 20;94(6):417-21 PMID: 11904313
Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
2003-06-00
Pages
1747-57
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC1868128
Subset
IM
Grants
NCI NIH HHS · P01 CA92644 · United States
NCI NIH HHS · R01 CA050453 · United States
NCI NIH HHS · P01 CA092644 · United States
NHLBI NIH HHS · HL-59316 · United States
NCI NIH HHS · CA-50453 · United States
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