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PMID: 12762803 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Brominated polyacetylenes from the Philippines sponge Diplastrella sp.

Journal of natural products ·Vol. 66 ·No. 5 ·2003-05-00 ·Pages 667-70

Lerch ML, Harper MK, Faulkner DJ

Abstract

Five novel brominated polyacetylenic diols, diplynes A-E (2-6), and three sulfated analogues, diplyne A 1-sulfate (7), diplyne C 1-sulfate (8), and 2-deoxydiplyne D sulfate (9), were isolated from the Philippines sponge Diplastrella sp. by employing bioassay-guided fractionation using the HIV-1 integrase inhibition assay. The novel metabolites were characterized by interpretation of spectroscopic data.

MeSH Terms
Acetylene/analogs & derivatives,chemistry,isolation & purification,pharmacology Animals Electron Spin Resonance Spectroscopy HIV Integrase Inhibitors/chemistry,isolation & purification,pharmacology Hydrocarbons, Brominated/chemistry,isolation & purification,pharmacology Inhibitory Concentration 50 Molecular Structure Philippines Polymers/chemistry,isolation & purification,pharmacology Polyynes Porifera/chemistry
Chemicals
HIV Integrase Inhibitors Hydrocarbons, Brominated Polymers Polyynes Acetylene
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Lerch Melissa L
Scripps Institution of Oceanography, University of California at San Diego, 9500 Gilman Drive, La Jolla 92093-0212, USA. [email protected]
Harper Mary Kay
Faulkner D John
Article Info
Journal
Journal of natural products
Abbr.
J Nat Prod
ISSN
0163-3864
DOI
10.1021/np020544+
Email
[email protected]
Published
2003-05-00
Pages
667-70
Language
English
Region
United States
NLM ID
7906882
Subset
IM
Grants
NCI NIH HHS · CA-49084 · United States
NCI NIH HHS · CA-67775 · United States
NIGMS NIH HHS · GM 56553 · United States
External Links
PubMed source DOI: 10.1021/np020544+ View journal details
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