Association of HLA-A3 and HLA-B14 antigens with idiopathic haemochromatosis.
The frequency of HLA-A3 and HLA-B14 antigens was significantly higher in a series of 51 patients with idiopathic haemochromatosis than in a control group, being respectively 78-4 versus 27-0% and 25-5 versus 3-4%. This finding strongly supports the suggestion that idiopathic haemochromatosis is a genetic disease and suggests that the gene(s) responsible for the disease may be linked to the histocompatibility genes.
7 references, click to expand
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Ankylosing spondylitis and HL-A 27.Lancet. 1973 Apr 28;1(7809):904-7 PMID: 4123836
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High association of an HL-A antigen, W27, with ankylosing spondylitis.N Engl J Med. 1973 Apr 5;288(14):704-6 PMID: 4688372
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HL-A and disease associations--a survey.Transplant Rev. 1975;22:3-43 PMID: 46644
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The association of the HL-A antigens with diseases.Clin Immunol Immunopathol. 1974 Sep;3(1):127-49 PMID: 4611669
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Idiopathic haemochromatosis: an autosomal recessive disease.Clin Genet. 1974;5(3):234-41 PMID: 4838891
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[Letter: Idiopathic hemochromatosis associated with HL-A 3 tissular antigen].Nouv Presse Med. 1975 May 10;4(19):1432 PMID: 1153315
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