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PMID: 12787743 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

The origin and maintenance of virulence for the human pathogenic fungus Cryptococcus neoformans.

Microbes and infection ·Vol. 5 ·No. 7 ·2003-06-00 ·Pages 667-75

Steenbergen JN, Casadevall A

Abstract

The origin of virulence in environmental fungi that have no requirement for animal hosts in their life cycle is enigmatic. Cryptococcus neoformans is a human pathogenic fungus with virulence factors for mammalian pathogenesis that also contribute to environmental survival. C. neoformans virulence may originate from selection pressures imposed by environmental predators.

MeSH Terms

Cryptococcosis/immunology,microbiology Cryptococcus neoformans/enzymology,genetics,pathogenicity Evolution, Molecular Gene Expression Regulation, Fungal Humans Macrophages/microbiology Virulence Virulence Factors/metabolism

Chemicals

Virulence Factors

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Steenbergen Judith N

Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Casadevall Arturo

Article Info

Journal

Microbes and infection

Abbr.

Microbes Infect

ISSN

1286-4579

DOI

10.1016/s1286-4579(03)00092-3

Published

2003-06-00

Pages

667-75

Language

English

Region

France

NLM ID

100883508

Subset

Grants

NIAID NIH HHS · AI13342 · United States

NIAID NIH HHS · AI33774 · United States

NHLBI NIH HHS · HL59842 · United States

NIGMS NIH HHS · T32GM 07491 · United States

External Links

PubMed source DOI: 10.1016/s1286-4579(03)00092-3 View journal details

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The origin and maintenance of virulence for the human pathogenic fungus Cryptococcus neoformans.

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