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PMID: 12802326 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Adaptive evolution drives divergence of a hybrid inviability gene between two species of Drosophila.

Nature ·Vol. 423 ·No. 6941 ·2003-06-12 ·Pages 715-9

Presgraves DC, Balagopalan L, Abmayr SM, Orr HA

Abstract

Speciation--the splitting of one species into two--occurs by the evolution of any of several forms of reproductive isolation between taxa, including the intrinsic sterility and inviability of hybrids. Abundant evidence shows that these hybrid fitness problems are caused by incompatible interactions between loci: new alleles that become established in one species are sometimes functionally incompatible with alleles at interacting loci from another species. However, almost nothing is known about the genes involved in such hybrid incompatibilities or the evolutionary forces that drive their divergence. Here we identify a gene that causes epistatic inviability in hybrids between two fruitfly species, Drosophila melanogaster and D. simulans. Our population genetic analysis reveals that this gene--which encodes a nuclear pore protein--evolved by positive natural selection in both species' lineages. These results show that a lethal hybrid incompatibility has evolved as a by-product of adaptive protein evolution.

MeSH Terms

Adaptation, Biological Alleles Amino Acid Motifs Amino Acid Sequence Animals Drosophila/classification,genetics Drosophila Proteins/chemistry,genetics Drosophila melanogaster/genetics Epistasis, Genetic Evolution, Molecular Female Genes, Insect/genetics Genes, Lethal/genetics Genetic Complementation Test Hybridization, Genetic/genetics Male Molecular Sequence Data Mutation, Missense/genetics Nuclear Pore Complex Proteins/chemistry,genetics Species Specificity

Chemicals

Drosophila Proteins Nuclear Pore Complex Proteins nuclear pore complex protein 96 nuclear pore complex protein 98

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Presgraves Daven C

Department of Biology, University of Rochester, Rochester, New York 14627, USA. [email protected]

Balagopalan Lakshmi

Abmayr Susan M

Orr H Allen

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/nature01679

[email protected]

Published

2003-06-12

Pages

715-9

Language

English

Region

England

NLM ID

0410462

Subset

Databases

GENBANK

AY250768, AY250769, AY250770, AY250771, AY250772, AY250773, AY250774, AY250775, AY250776, AY250777, AY250778, AY250779, AY250780, AY250781, AY250782, AY250783, AY250784, AY250785, AY250786, AY250787, AY250788, AY250789, AY250790, AY250791, AY250792, AY250793, AY250794, AY250795, AY250796, AY250797, AY250798, AY250799, AY250800

Corrections

CommentIn

PMID: 12802320

External Links

PubMed source DOI: 10.1038/nature01679 View journal details

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Adaptive evolution drives divergence of a hybrid inviability gene between two species of Drosophila.

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