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PMID: 12807474 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The peripheral generation of CD4+ CD25+ regulatory T cells.

Immunology ·Vol. 109 ·No. 3 ·2003-07-00 ·Pages 319-25

Akbar AN, Taams LS, Salmon M, Vukmanovic-Stejic M

Abstract

暂无摘要

MeSH Terms
Apoptosis/immunology CD4-Positive T-Lymphocytes/immunology Cell Differentiation/immunology Clonal Anergy/immunology Humans Receptors, Interleukin-2/analysis T-Lymphocyte Subsets/immunology Thymus Gland/immunology
Chemicals
Receptors, Interleukin-2
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Akbar Arne N
Department of Immunology and Molecular Pathology, Windeyer Institute for Medical Sciences, Royal Free and University College Medical School, London, UK. [email protected]
Taams Leonie S
Salmon Mike
Vukmanovic-Stejic Milica
References (73)
73 references, click to expand
  1. Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry.
    Nat Biotechnol. 1998 Aug;16(8):743-7 PMID: 9702772
  2. Regulation of telomere length and telomerase in T and B cells: a mechanism for maintaining replicative potential.
    Immunity. 1998 Aug;9(2):151-7 PMID: 9729035
  3. Anti-CD4 monoclonal antibody-induced tolerance to MHC-incompatible cardiac allografts maintained by CD4+ suppressor T cells that are not dependent upon IL-4.
    J Immunol. 1998 Nov 15;161(10):5147-56 PMID: 9820484
  4. Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.
    Int Immunol. 1998 Dec;10(12):1969-80 PMID: 9885918
  5. Type I interferons keep activated T cells alive.
    J Exp Med. 1999 Feb 1;189(3):521-30 PMID: 9927514
  6. Dose-dependent induction of distinct anergic phenotypes: multiple levels of T cell anergy.
    J Immunol. 1999 Feb 15;162(4):1974-81 PMID: 9973467
  7. Mature T lymphocyte apoptosis--immune regulation in a dynamic and unpredictable antigenic environment.
    Annu Rev Immunol. 1999;17:221-53 PMID: 10358758
  8. Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood.
    J Exp Med. 1999 Jul 19;190(2):157-67 PMID: 10432279
  9. Inhibition of T cell apoptosis by IFN-beta rapidly reverses nuclear translocation of protein kinase C-delta.
    Eur J Immunol. 1999 Aug;29(8):2603-12 PMID: 10458775
  10. Characterization of human CD25+ CD4+ T cells in thymus, cord and adult blood.
    Immunology. 2002 Jun;106(2):190-9 PMID: 12047748
  11. CD4+ CD25+ suppressor T cells: more questions than answers.
    Nat Rev Immunol. 2002 Jun;2(6):389-400 PMID: 12093005
  12. Antigen-specific T cell suppression by human CD4+CD25+ regulatory T cells.
    Eur J Immunol. 2002 Jun;32(6):1621-30 PMID: 12115645
  13. Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers.
    J Immunol. 2002 Nov 1;169(9):4850-60 PMID: 12391195
  14. Anergic T cells act as suppressor cells in vitro and in vivo.
    Eur J Immunol. 1999 Feb;29(2):686-92 PMID: 10064086
  15. Interferon-beta mediates stromal cell rescue of T cells from apoptosis.
    Eur J Immunol. 1999 Mar;29(3):1041-50 PMID: 10092109
  16. Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance.
    J Immunol. 1999 May 1;162(9):5317-26 PMID: 10228007
  17. Antigen presentation by T cells versus professional antigen-presenting cells (APC): differential consequences for T cell activation and subsequent T cell-APC interactions.
    Eur J Immunol. 1999 May;29(5):1543-50 PMID: 10359108
  18. Control of intestinal inflammation by regulatory T cells.
    Immunol Rev. 2001 Aug;182:190-200 PMID: 11722634
  19. In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines.
    J Exp Med. 2002 Mar 4;195(5):603-16 PMID: 11877483
  20. Control of regulatory T cell development by the transcription factor Foxp3.
    Science. 2003 Feb 14;299(5609):1057-61 PMID: 12522256
  21. T cell anergy.
    Annu Rev Immunol. 2003;21:305-34 PMID: 12471050
  22. Regulatory T cells under scrutiny.
    Nat Rev Immunol. 2003 Mar;3(3):189-98 PMID: 12658267
  23. The role of chemokine receptors in primary, effector, and memory immune responses.
    Annu Rev Immunol. 2000;18:593-620 PMID: 10837070
  24. Regulatory T cells: key controllers of immunologic self-tolerance.
    Cell. 2000 May 26;101(5):455-8 PMID: 10850488
  25. Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation.
    J Exp Med. 2000 Jul 17;192(2):295-302 PMID: 10899916
  26. The role of telomerase expression and telomere length maintenance in human and mouse.
    J Clin Immunol. 2000 Jul;20(4):257-67 PMID: 10939713
  27. CD25 is a marker for CD4+ thymocytes that prevent autoimmune diabetes in rats, but peripheral T cells with this function are found in both CD25+ and CD25- subpopulations.
    J Immunol. 2000 Sep 15;165(6):3105-10 PMID: 10975823
  28. Type 1 IFN maintains the survival of anergic CD4+ T cells.
    J Immunol. 2000 Oct 1;165(7):3782-9 PMID: 11034383
  29. Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells.
    J Exp Med. 2000 Nov 6;192(9):1213-22 PMID: 11067871
  30. Human anergic/suppressive CD4(+)CD25(+) T cells: a highly differentiated and apoptosis-prone population.
    Eur J Immunol. 2001 Apr;31(4):1122-31 PMID: 11298337
  31. Human CD4(+)CD25(+) thymocytes and peripheral T cells have immune suppressive activity in vitro.
    Eur J Immunol. 2001 Apr;31(4):1247-54 PMID: 11298351
  32. Regulating the immune response to transplants. a role for CD4+ regulatory cells?
    Immunity. 2001 Apr;14(4):399-406 PMID: 11336685
  33. Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood.
    J Exp Med. 2001 Jun 4;193(11):1285-94 PMID: 11390435
  34. Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function.
    J Exp Med. 2001 Jun 4;193(11):1295-302 PMID: 11390436
  35. Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood.
    J Exp Med. 2001 Jun 4;193(11):1303-10 PMID: 11390437
  36. Generation of anergic and potentially immunoregulatory CD25+CD4 T cells in vivo after induction of peripheral tolerance with intravenous or oral antigen.
    J Immunol. 2001 Jul 1;167(1):188-95 PMID: 11418648
  37. Regulatory T cells induced by 1 alpha,25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance.
    J Immunol. 2001 Aug 15;167(4):1945-53 PMID: 11489974
  38. Regulatory T cells in the control of immune pathology.
    Nat Immunol. 2001 Sep;2(9):816-22 PMID: 11526392
  39. Activation of CD25(+)CD4(+) regulatory T cells by oral antigen administration.
    J Immunol. 2001 Oct 15;167(8):4245-53 PMID: 11591746
  40. Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells.
    Blood. 2001 Nov 1;98(9):2736-44 PMID: 11675346
  41. Immunoregulation in the tissues by gammadelta T cells.
    Nat Rev Immunol. 2003 Mar;3(3):233-42 PMID: 12658271
  42. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells.
    Nat Immunol. 2003 Apr;4(4):330-6 PMID: 12612578
  43. Ia determinants on stimulated human T lymphocytes. Occurrence on mitogen- and antigen-activated T cells.
    J Exp Med. 1979 Aug 1;150(2):246-55 PMID: 88499
  44. Study on cellular events in postthymectomy autoimmune oophoritis in mice. I. Requirement of Lyt-1 effector cells for oocytes damage after adoptive transfer.
    J Exp Med. 1982 Dec 1;156(6):1565-76 PMID: 6983557
  45. Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis.
    J Exp Med. 1982 Dec 1;156(6):1577-86 PMID: 6983558
  46. Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin.
    J Exp Med. 1983 May 1;157(5):1434-47 PMID: 6189936
  47. Early signaling defects in human T cells anergized by T cell presentation of autoantigen.
    J Exp Med. 1992 Jul 1;176(1):177-86 PMID: 1535366
  48. Telomere end-replication problem and cell aging.
    J Mol Biol. 1992 Jun 20;225(4):951-60 PMID: 1613801
  49. The significance of low bcl-2 expression by CD45RO T cells in normal individuals and patients with acute viral infections. The role of apoptosis in T cell memory.
    J Exp Med. 1993 Aug 1;178(2):427-38 PMID: 8340752
  50. A possible role for bcl-2 in regulating T-cell memory--a 'balancing act' between cell death and survival.
    Immunol Today. 1993 Nov;14(11):526-32 PMID: 8274194
  51. The progressive differentiation of primed T cells is associated with an increasing susceptibility to apoptosis.
    Eur J Immunol. 1994 Apr;24(4):892-9 PMID: 8149960
  52. Anergic T cells as suppressor cells in vitro.
    Science. 1994 Jun 10;264(5165):1587-9 PMID: 8202711
  53. Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age.
    Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9857-60 PMID: 7937905
  54. Tissue-specific suppressor T cells involved in self-tolerance are activated extrathymically by self-antigens.
    Immunology. 1994 Jul;82(3):365-9 PMID: 7959869
  55. Activated rat T cells synthesize and express functional major histocompatibility class II antigens.
    Immunology. 1995 Feb;84(2):193-201 PMID: 7750994
  56. Telomere shortening is associated with cell division in vitro and in vivo.
    Exp Cell Res. 1995 Sep;220(1):194-200 PMID: 7664836
  57. Human naive and memory T lymphocytes differ in telomeric length and replicative potential.
    Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):11091-4 PMID: 7479943
  58. Immunological memory and protective immunity: understanding their relation.
    Science. 1996 Apr 5;272(5258):54-60 PMID: 8600537
  59. Antigen presentation by T cells inhibits IL-2 production and induces IL-4 release due to altered cognate signals.
    J Immunol. 1996 Apr 15;156(8):2769-75 PMID: 8609395
  60. Interleukin-2 receptor common gamma-chain signaling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal: selective induction of anti-apoptotic (bcl-2, bcl-xL) but not pro-apoptotic (bax, bcl-xS) gene expression.
    Eur J Immunol. 1996 Feb;26(2):294-9 PMID: 8617294
  61. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation.
    J Exp Med. 1996 Aug 1;184(2):387-96 PMID: 8760792
  62. Mechanism of telomerase induction during T cell activation.
    Exp Cell Res. 1996 Oct 10;228(1):58-64 PMID: 8892971
  63. Amplification of natural regulatory immune mechanisms for transplantation tolerance.
    Transplantation. 1996 Nov 15;62(9):1200-6 PMID: 8932256
  64. The thymus contains a high frequency of cells that prevent autoimmune diabetes on transfer into prediabetic recipients.
    J Exp Med. 1996 Dec 1;184(6):2393-8 PMID: 8976193
  65. Dissociation of T cell anergy from apoptosis by blockade of Fas/Apo-1 (CD95) signaling.
    J Immunol. 1997 Apr 1;158(7):3099-107 PMID: 9120262
  66. Changes in telomerase activity and telomere length during human T lymphocyte senescence.
    Exp Cell Res. 1997 Mar 15;231(2):346-53 PMID: 9087176
  67. Replicative senescence of T cells: does the Hayflick Limit lead to immune exhaustion?
    Immunol Today. 1997 Sep;18(9):450-4 PMID: 9293162
  68. Tales of tails: regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation, and aging.
    Immunol Rev. 1997 Dec;160:43-54 PMID: 9476664
  69. Cytokine-induced survival of activated T cells in vitro and in vivo.
    Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3810-5 PMID: 9520449
  70. Antigen presentation by epithelial cells induces anergic immunoregulatory CD45RO+ T cells and deletion of CD45RA+ T cells.
    J Immunol. 1997 Dec 15;159(12):5853-61 PMID: 9550381
  71. Differences between responses of naive and activated T cells to anergy induction.
    J Immunol. 1998 Jan 1;160(1):33-8 PMID: 9551953
  72. T cell memory.
    Annu Rev Immunol. 1998;16:201-23 PMID: 9597129
  73. Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency.
    Int Immunol. 1998 Apr;10(4):371-8 PMID: 9620592
Article Info
Journal
Immunology
Abbr.
Immunology
ISSN
0019-2805
DOI
10.1046/j.1365-2567.2003.01678.x
Email
[email protected]
Published
2003-07-00
Pages
319-25
Language
English
Region
England
NLM ID
0374672
PMCID
PMC1782989
Subset
IM
External Links
PubMed source DOI: 10.1046/j.1365-2567.2003.01678.x PMC Full Text View journal details
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