MicroRNA pathways in flies and worms: growth, death, fat, stress, and timing.

Cell ·Vol. 113 ·No. 6 ·2003-06-13 ·Pages 673-6

Ambros V

Abstract

Drosophila geneticists have uncovered roles for microRNAs in the coordination of cell proliferation and cell death during development, and in stress resistance and fat metabolism. In C. elegans, a homolog of the well-known fly developmental regulator hunchback acts downstream of the microRNAs lin-4 and let-7 in a pathway controlling developmental timing.

MeSH Terms

Animals Apoptosis/genetics Caenorhabditis elegans/genetics,growth & development Cell Division/genetics Drosophila melanogaster/genetics,growth & development Gene Expression Regulation, Developmental/genetics MicroRNAs/genetics Protein Biosynthesis/genetics RNA, Messenger/genetics

Chemicals

MicroRNAs RNA, Messenger

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Ambros Victor

Dartmouth Medical School, Department of Genetics, Hanover, NH 03755, USA. [email protected]

Article Info

Journal

Cell

Abbr.

Cell

ISSN

0092-8674

DOI

10.1016/s0092-8674(03)00428-8

[email protected]

Published

2003-06-13

Pages

673-6

Language

English

Region

United States

NLM ID

0413066

Subset

Corrections

ErratumIn

External Links

PubMed source DOI: 10.1016/s0092-8674(03)00428-8 View journal details

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MicroRNA pathways in flies and worms: growth, death, fat, stress, and timing.

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