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PMID: 12815500 Published · ppublish English Journal Article Review

Cognitive reserve and lifestyle.

Journal of clinical and experimental neuropsychology ·Vol. 25 ·No. 5 ·2003-08-00 ·Pages 625-33

Scarmeas N, Stern Y

Abstract

The concept of cognitive reserve (CR) suggests that innate intelligence or aspects of life experience like educational or occupational attainments may supply reserve, in the form of a set of skills or repertoires that allows some people to cope with progressing Alzheimer's disease (AD) pathology better than others. There is epidemiological evidence that lifestyle characterized by engagement in leisure activities of intellectual and social nature is associated with slower cognitive decline in healthy elderly and may reduce the risk of incident dementia. There is also evidence from functional imaging studies that subjects engaging in such leisure activities can clinically tolerate more AD pathology. It is possible that aspects of life experience like engagement in leisure activities may result in functionally more efficient cognitive networks and therefore provide a CR that delays the onset of clinical manifestations of dementia.

MeSH Terms
Adaptation, Physiological Adaptation, Psychological Aged Aged, 80 and over Alzheimer Disease/epidemiology,physiopathology Brain Cognition/physiology Cognition Disorders/epidemiology,physiopathology Educational Status Exercise Health Behavior Humans Life Style Middle Aged Nerve Net/physiology Neuronal Plasticity/physiology Recruitment, Neurophysiological/physiology Risk Factors Severity of Illness Index
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Scarmeas Nikolaos
Cognitive Neuroscience Division, Department of Neurology, Taub Institute for Research in Alzheimer's Disease and the Aging Brain, and College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. [email protected]
Stern Yaakov
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Article Info
Journal
Journal of clinical and experimental neuropsychology
Abbr.
J Clin Exp Neuropsychol
ISSN
1380-3395
DOI
10.1076/jcen.25.5.625.14576
Email
[email protected]
Published
2003-08-00
Pages
625-33
Language
English
Region
England
NLM ID
8502170
PMCID
PMC3024591
Subset
IM
Grants
NIA NIH HHS · R01 AG014671-03 · United States
External Links
PubMed source DOI: 10.1076/jcen.25.5.625.14576 PMC Full Text View journal details
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