Home LiteratureArticle Details
PMID: 1281632 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Group A streptococcal M proteins: virulence factors and protective antigens.

Immunology today ·Vol. 13 ·No. 9 ·1992-09-00 ·Pages 362-7

Robinson JH, Kehoe MA

Abstract

Rebecca Lancefield described group A streptococcal M proteins over 50 years ago, and they have remained at the forefront of investigations into streptococcal pathogenicity to the present day. As described in this review, they form cell surface fibrils with several functions, ranging from resisting phagocytosis and inducing host-crossreactive antibodies, to presenting the host immune system with an accessible protective antigen.

Related Genes
V&bgr
MeSH Terms
Animals Antigens, Bacterial/genetics,immunology Autoimmune Diseases/etiology,immunology Bacterial Outer Membrane Proteins Bacterial Proteins/genetics,immunology Bacterial Vaccines Carrier Proteins Cross Reactions Epitopes/immunology Humans Mice Mice, Inbred Strains/immunology Phagocytosis Protein Conformation Protein Structure, Secondary Receptors, Antigen, T-Cell/genetics,immunology Repetitive Sequences, Nucleic Acid Sequence Homology, Amino Acid Streptococcal Infections/complications,immunology Streptococcus pyogenes/immunology,pathogenicity T-Lymphocyte Subsets/immunology Virulence
Chemicals
Antigens, Bacterial Bacterial Outer Membrane Proteins Bacterial Proteins Bacterial Vaccines Carrier Proteins Epitopes Receptors, Antigen, T-Cell streptococcal M protein
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Robinson J H
Dept of Immunology, Medical School, University of Newcastle upon Tyne, UK.
Kehoe M A
Article Info
Journal
Immunology today
Abbr.
Immunol Today
ISSN
0167-5699
DOI
10.1016/0167-5699(92)90173-5
Published
1992-09-00
Pages
362-7
Language
English
Region
England
NLM ID
8008346
Subset
IM
Grants
Wellcome Trust · United Kingdom
External Links
PubMed source DOI: 10.1016/0167-5699(92)90173-5
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2