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PMID: 12819898 Published · ppublish English Journal Article Meta-Analysis Research Support, Non-U.S. Gov't

Gly972Arg variant in the insulin receptor substrate-1 gene and association with Type 2 diabetes: a meta-analysis of 27 studies.

Diabetologia ·Vol. 46 ·No. 7 ·2003-07-00 ·Pages 990-5

Jellema A, Zeegers MP, Feskens EJ, Dagnelie PC, Mensink RP

Abstract

Several case-control studies have examined the association between the Gly972Arg variant in the IRS-1 gene and Type 2 diabetes, but most had limited power and results could therefore be conflicting. We systematically reviewed the literature by means of a meta-analysis and investigated sources of heterogeneity in results of different studies. The summary risk ratio, based on 3408 cases and 5419 control cases from 27 studies, was 1.25 (95% CI 1.05-1.48). The results, however, differed according to the type of study, method of verifying non-diabetic status of the control subjects, and age of the case subjects. Population-based studies reported lower odds ratios than hospital-based studies (OR 0.98, 95% CI 0.74-1.30 vs OR 1.43, 95% CI 1.17-1.74). Also, the diagnostic test to exclude diabetes amongst control subjects interacted with the association between the IRS-1 Gly972Arg variant and Type 2 diabetes (p=0.03). Finally, the odds ratio reduced with increasing age ( p=0.03). Overall, carriers of the 972Arg variant of the IRS-1 gene are at a 25% increased risk of having Type 2 diabetes compared with non-carriers. The odds ratios are generally higher in hospital-based studies, including relatively young, symptomatic, cases.

MeSH Terms
Amino Acid Substitution/genetics Arginine/genetics Diabetes Mellitus/genetics Diabetes Mellitus, Type 2/genetics Genetic Carrier Screening Genetic Variation/genetics Glycine/genetics Humans Insulin Receptor Substrate Proteins Obesity Odds Ratio Phosphoproteins/genetics Racial Groups/genetics
Chemicals
IRS1 protein, human Insulin Receptor Substrate Proteins Phosphoproteins Arginine Glycine
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Jellema A
Centre for Nutrition and Health, National Institute for Public Health and the Environment, Bilthoven, The Netherlands. [email protected]
Zeegers M P A
Feskens E J M
Dagnelie P C
Mensink R P
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Article Info
Journal
Diabetologia
Abbr.
Diabetologia
ISSN
0012-186X
DOI
10.1007/s00125-003-1126-4
Email
[email protected]
Published
2003-07-00
Epub
2003-00-18
Pages
990-5
Language
English
Region
Germany
NLM ID
0006777
Subset
IM
External Links
PubMed source DOI: 10.1007/s00125-003-1126-4 View journal details
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