CD40 and its ligand, an essential ligand-receptor pair for thymus-dependent B-cell activation.

Immunology today ·Vol. 13 ·No. 11 ·1992-11-00 ·Pages 431-3

Noelle RJ, Ledbetter JA, Aruffo A

Abstract

The discovery of CD40 and its ligand, gp39, have created new perspectives on the activation of resting B cells by TH cells. Here, Randolph Noelle, Jeffrey Ledbetter and Alejandro Aruffo describe how these molecules were characterized and, from recent findings, examine their relevance to immune activation.

MeSH Terms

Animals Antigens, CD/physiology Antigens, Differentiation, B-Lymphocyte/physiology B-Lymphocytes/immunology CD40 Antigens CD40 Ligand DNA/genetics Humans Ligands Lymphocyte Activation Lymphocyte Cooperation Membrane Glycoproteins/genetics,physiology Membrane Proteins/genetics,physiology Mice Recombinant Fusion Proteins/pharmacology Sequence Homology, Amino Acid Signal Transduction T-Lymphocytes, Helper-Inducer/immunology

Chemicals

Antigens, CD Antigens, Differentiation, B-Lymphocyte CD40 Antigens Ligands Membrane Glycoproteins Membrane Proteins Recombinant Fusion Proteins CD40 Ligand DNA

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Noelle R J

Dept of Microbiology, Dartmouth Medical School, Lebanon, NH 03756.

Ledbetter J A

Aruffo A

Article Info

Journal

Immunology today

Abbr.

Immunol Today

ISSN

0167-5699

DOI

10.1016/0167-5699(92)90068-I

Published

1992-11-00

Pages

431-3

Language

English

Region

England

NLM ID

8008346

Subset

External Links

PubMed source DOI: 10.1016/0167-5699(92)90068-I

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CD40 and its ligand, an essential ligand-receptor pair for thymus-dependent B-cell activation.

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