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PMID: 12831879 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Recognition of the DNA minor groove by pyrrole-imidazole polyamides.

Current opinion in structural biology ·Vol. 13 ·No. 3 ·2003-06-00 ·Pages 284-99

Dervan PB, Edelson BS

Abstract

Many diseases, such as cancer, are related to aberrant gene expression. Regulating transcription by chemical methods could be important in human medicine. Minor groove-binding polyamides offer one chemical approach to DNA recognition.

MeSH Terms
Base Sequence Benzimidazoles/metabolism Binding Sites DNA/chemistry,metabolism DNA-Binding Proteins/metabolism Gene Expression Regulation Imidazoles/metabolism Molecular Sequence Data Nucleic Acid Conformation Nylons/metabolism Pyrroles/metabolism
Chemicals
Benzimidazoles DNA-Binding Proteins Imidazoles Nylons Pyrroles imidazole DNA
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Dervan Peter B
Division of Chemistry and Chemical Engineering, and Beckman Institute, California Institute of Technology, Pasadena, CA 91125, USA. [email protected]
Edelson Benjamin S
Article Info
Journal
Current opinion in structural biology
Abbr.
Curr Opin Struct Biol
ISSN
0959-440X
DOI
10.1016/s0959-440x(03)00081-2
Email
[email protected]
Published
2003-06-00
Pages
284-99
Language
English
Region
England
NLM ID
9107784
Subset
IM
External Links
PubMed source DOI: 10.1016/s0959-440x(03)00081-2 View journal details
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