Trinuclear Cu(II) complex for internucleoside linkage-specific cleavage of RNA.

Nucleic acids research. Supplement (2001) ·No. 1 ·2003-08-15

Matsumura K, Kina S, Sumaoka J, Tobey S, Anslyn E V, Komiyama M

Abstract

Trinuclear Cu(II) complex of N,N,N',N',N",N"-hexa[(2-pyridyl)methyl]-1,3,5-tris(aminomethyl)benzene (L3A) exhibits remarkable substrate-specificity for hydrolysis of 2'-->5' and 3'-->5' ribonucleotides. Up(2'-->5')U is hydrolyzed much efficiently than is Up(3'-->5')U, but Ap(3'-->5')A is overwhelmingly preferable to Ap(2'-->5')A.

Article Info

Journal

Nucleic acids research. Supplement (2001)

Abbr.

Nucleic Acids Res Suppl

Published

2003-08-15

Indexed

2003-07-02

Updated

2013-11-21

Language

English

Country/Region

England

NLM ID

101169367

External Links

PubMed source

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Trinuclear Cu(II) complex for internucleoside linkage-specific cleavage of RNA.

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