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PMID: 12848902 Published · ppublish English Clinical Trial Controlled Clinical Trial Journal Article Multicenter Study Research Support, U.S. Gov't, P.H.S.

The Ischemic Stroke Genetics Study (ISGS) Protocol.

BMC neurology ·Vol. 3 ·2003-07-08 ·Pages 4

Meschia JF, Brott TG, Brown RD, Crook RJ, Frankel M, Hardy J, Merino JG, Rich SS, Silliman S, Worrall BB, Ischemic Stroke Genetics Study

Abstract

The molecular basis for the genetic risk of ischemic stroke is likely to be multigenic and influenced by environmental factors. Several small case-control studies have suggested associations between ischemic stroke and polymorphisms of genes that code for coagulation cascade proteins and platelet receptors. Our aim is to investigate potential associations between hemostatic gene polymorphisms and ischemic stroke, with particular emphasis on detailed characterization of the phenotype. The Ischemic Stroke Genetic Study is a prospective, multicenter genetic association study in adults with recent first-ever ischemic stroke confirmed with computed tomography or magnetic resonance imaging. Patients are evaluated at academic medical centers in the United States and compared with sex- and age-matched controls. Stroke subtypes are determined by central blinded adjudication using standardized, validated mechanistic and syndromic classification systems. The panel of genes to be tested for polymorphisms includes beta-fibrinogen and platelet glycoprotein Ia, Iba, and IIb/IIIa. Immortalized cell lines are created to allow for time- and cost-efficient testing of additional candidate genes in the future. The study is designed to minimize survival bias and to allow for exploring associations between specific polymorphisms and individual subtypes of ischemic stroke. The data set will also permit the study of genetic determinants of stroke outcome. Having cell lines will permit testing of future candidate risk factor genes.

MeSH Terms
Academic Medical Centers Adult Brain Ischemia/complications,genetics Case-Control Studies Cell Line Clinical Protocols Female Fibrinogen/genetics Follow-Up Studies Gene Expression Profiling Humans Male Platelet Membrane Glycoproteins/genetics Polymorphism, Genetic/genetics Prospective Studies Reference Values Sample Size Stroke/complications,genetics United States
Chemicals
Platelet Membrane Glycoproteins Fibrinogen
Authors & Affiliations
11 authors, click to expand affiliations / ORCID
Meschia James F
Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA. [email protected]
Brott Thomas G
Brown Robert D
Crook Richard J P
Frankel Michael
Hardy John
Merino José G
Rich Stephen S
Silliman Scott
Worrall Bradford Burke
Ischemic Stroke Genetics Study
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Article Info
Journal
BMC neurology
Abbr.
BMC Neurol
ISSN
1471-2377
DOI
10.1186/1471-2377-3-4
Email
[email protected]
Published
2003-07-08
Epub
2003-00-08
Pages
4
Language
English
Region
England
NLM ID
100968555
PMCID
PMC184375
Subset
IM
Grants
NINDS NIH HHS · R01 NS-42733 · United States
External Links
PubMed source DOI: 10.1186/1471-2377-3-4 PMC Full Text View journal details
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