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PMID: 12879310 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Complementary DNA sequences encoding the rat MHC class II RT1-Bu and RT1-Du alpha and beta chains.

Immunogenetics ·Vol. 55 ·No. 5 ·2003-08-00 ·Pages 344-50

Easterfield AJ, Bradley JA, Bolton EM

Abstract

The rat major histocompatibility complex loci RT1-B and RT1-D are equivalent to the human leucocyte antigens HLA-DQ and HLA-DR respectively. Here we describe the complementary DNA (cDNA) sequence encoding the alpha and beta chains of both the RT1-B and RT1-D locus genes of the rat RT1u haplotype. We have found entire sequence identity between five different inbred rat strains of the RT1u haplotype, which differs from previously published, incomplete sequences. This information is of considerable value for experimental studies of transplantation immunity and autoimmune disease.

MeSH Terms
Animals Base Sequence DNA, Complementary Histocompatibility Antigens/genetics Histocompatibility Antigens Class II/genetics Molecular Sequence Data Polymerase Chain Reaction Rats
Chemicals
DNA, Complementary Histocompatibility Antigens Histocompatibility Antigens Class II histocompatibility antigens RT, rat
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Easterfield Alistair J
Department of Surgery, University of Cambridge School of Clinical Medicine, Box 202, Addenbrooke's Hospital, Cambridge, CB2 2QQ, UK.
Bradley J Andrew
Bolton Eleanor M
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Article Info
Journal
Immunogenetics
Abbr.
Immunogenetics
ISSN
0093-7711
DOI
10.1007/s00251-003-0584-7
Published
2003-08-00
Epub
2003-00-18
Pages
344-50
Language
English
Region
United States
NLM ID
0420404
Subset
IM
Databases
GENBANK
AJ554214, AJ554215, AJ554216
External Links
PubMed source DOI: 10.1007/s00251-003-0584-7 View journal details
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