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PMID: 12925735 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Estimating the distribution of fitness effects from DNA sequence data: implications for the molecular clock.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 100 ·No. 18 ·2003-09-02 ·Pages 10335-40

Piganeau G, Eyre-Walker A

Abstract

We present a method for estimating the distribution of fitness effects of new amino acid mutations when those mutations can be assumed to be slightly advantageous, slightly deleterious, or strongly deleterious. We apply the method to mitochondrial data from several different species. In the majority of the data sets, the shape of the distribution is approximately exponential. Our results provide an estimate of the distribution of fitness effects of weakly selected mutations and provide a possible explanation for why the molecular clock is fairly constant across taxa and time.

MeSH Terms
Animals Base Sequence DNA/chemistry Humans Mutation/genetics
Chemicals
DNA
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Piganeau Gwenaël
Centre for the Study of Evolution and School of Biological Sciences, University of Sussex, Brighton BN1 9QG, United Kingdom.
Eyre-Walker Adam
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.1833064100
Published
2003-09-02
Epub
2003-00-18
Pages
10335-40
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC193562
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.1833064100 PMC Full Text View journal details
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