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PMID: 12930746 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

A survey of chromosomal and nucleotide sequence variation in Drosophila miranda.

Genetics ·Vol. 164 ·No. 4 ·2003-08-00 ·Pages 1369-81

Yi S, Bachtrog D, Charlesworth B

Abstract

There have recently been several studies of the evolution of Y chromosome degeneration and dosage compensation using the neo-sex chromosomes of Drosophila miranda as a model system. To understand these evolutionary processes more fully, it is necessary to document the general pattern of genetic variation in this species. Here we report a survey of chromosomal variation, as well as polymorphism and divergence data, for 12 nuclear genes of D. miranda. These genes exhibit varying levels of DNA sequence polymorphism. Compared to its well-studied sibling species D. pseudoobscura, D. miranda has much less nucleotide sequence variation, and the effective population size of this species is inferred to be several-fold lower. Nevertheless, it harbors a few inversion polymorphisms, one of which involves the neo-X chromosome. There is no convincing evidence for a recent population expansion in D. miranda, in contrast to D. pseudoobscura. The pattern of population subdivision previously observed for the X-linked gene period is not seen for the other loci, suggesting that there is no general population subdivision in D. miranda. However, data on an additional region of period confirm population subdivision for this gene, suggesting that local selection is operating at or near period to promote differentiation between populations.

MeSH Terms
Alleles Animals Base Sequence/genetics Chromosome Inversion Chromosome Mapping Chromosomes/genetics Drosophila/genetics Drosophila Proteins Evolution, Molecular Exons Genes, Insect Genetic Linkage Genetic Variation Genetics, Population Molecular Sequence Data Nuclear Proteins/genetics Period Circadian Proteins Polymorphism, Genetic X Chromosome/genetics Y Chromosome/genetics
Chemicals
Drosophila Proteins Nuclear Proteins PER protein, Drosophila Period Circadian Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Yi Soojin
Department of Ecology and Evolution, University of Chicago, 1101 E. 57th Street, Chicago, IL 60637-1573, USA. [email protected]
Bachtrog Doris
Charlesworth Brian
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Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
DOI
10.1093/genetics/164.4.1369
Email
[email protected]
Published
2003-08-00
Pages
1369-81
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1462654
Subset
IM
Databases
GENBANK
AY238758, AY238759, AY238760, AY238761, AY238762, AY238763, AY238764, AY238765, AY238766, AY238767, AY238768, AY238769, AY238770, AY238771, AY238772, AY238773, AY238774, AY238775, AY238776, AY238777, AY238778, AY238779, AY238780, AY238781, AY238782, AY238783, AY238784, AY238785, AY238786, AY238787, AY238788, AY238789, AY238790, AY238791, AY238792, AY238793, AY238794, AY238795, AY238796, AY238797, AY238798, AY238799, AY238800, AY238801, AY238802, AY238803, AY238804, AY238805, AY238806, AY238807, AY238808, AY238809, AY238810, AY238811, AY238812, AY238813, AY238814, AY238815, AY238816, AY238817, AY238818, AY238819, AY238820, AY238821, AY238822, AY238823, AY238824, AY238825, AY238826, AY238827, AY238828, AY238829, AY238830, AY238831, AY238832, AY238833, AY238834, AY238835, AY238836, AY238837, AY238838, AY238839, AY238840, AY238841, AY238842, AY238843, AY238844, AY238845, AY238846, AY238847, AY238848, AY238849, AY238850, AY238851, AY238852, AY238853, AY238854, AY238855, AY238856, AY238857, AY238858, AY238859, AY238860, AY238861, AY238862, AY238863, AY238864, AY238865, AY238866, AY238867, AY238868, AY238869, AY238870, AY238871, AY238872, AY238873, AY238874, AY238875, AY238876, AY238877, AY238878, AY238879
External Links
PubMed source DOI: 10.1093/genetics/164.4.1369 PMC Full Text View journal details
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