Plasma inhibitors of lymphocyte response to phytohaemagglutinin in children with recurrent infections.

Immunology ·Vol. 30 ·No. 1 ·1976-01-00 ·Pages 33-42

Fitzgerald MG, Hosking CS

Abstract

A survey of the immunological status of 175 children with recurrent infections showed that the plasmas of fifteen patients contained an inhibitor of lymphocyte response to phytohaemagglutinin (PHA). The inhibitors could be subdivided into two groups. One type of inhibitor acted only on the patients' lymphocytes (autologous-only). The other type also inhibited the response of control lymphocytes to PHA and in the mixed lymphocyte reaction (homologous). Plasma inhibitors of both types inhibit the response of rabbit lymphocytes to PHA. Patients with a plasma inhibitor frequently have a raised resting lymphocyte DNA synthesis.

MeSH Terms

Animals Cells, Cultured Child Child, Preschool DNA/biosynthesis Depression, Chemical Female Humans Infant Infant, Newborn Infections/immunology Lectins Lymphocyte Activation Lymphocyte Culture Test, Mixed Lymphocytes/immunology,metabolism Male Rabbits Recurrence

Chemicals

Lectins DNA

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Fitzgerald M G

Hosking C S

References (16)

16 references, click to expand

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Article Info

Journal

Immunology

Abbr.

Immunology

ISSN

0019-2805

Published

1976-01-00

Pages

33-42

Language

English

Region

England

NLM ID

0374672

PMCID

PMC1444958

Subset

External Links

PubMed source PMC Full Text View journal details

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Plasma inhibitors of lymphocyte response to phytohaemagglutinin in children with recurrent infections.

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