Home LiteratureArticle Details
PMID: 12952080 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

AmpA, a modular protein containing disintegrin and ornatin domains, has multiple effects on cell adhesion and cell fate specification.

Journal of muscle research and cell motility ·Vol. 23 ·No. 7-8 ·2002-00-00 ·Pages 817-28

Blumberg DD, Ho HN, Petty CL, Varney TR, Gandham S

Abstract

Proteins containing disintegrin domains play a variety of roles in regulating processes involving adhesion, migration and cell type specification during development of many metazoan organisms. Most disintegrin domain containing proteins belong to the ADAM (a disintegrin and a metalloprotease) family of proteins that also contain a metalloprotease domain. Here we describe a small secreted protein from Dictyostelium that contains multiple repeated domains sharing homology with both the disintegrin motif and with a second class of fibrinogen receptor antagonists, the ornatins. This protein, called AmpA for its role in modulating adhesion, differs from the ADAM family proteins in that it lacks a metalloprotease domain. Nonetheless, it appears to be involved in the same complex spectrum of developmental functions as the metazoan ADAM family proteins. Here we review the structure and evolution of this protein and its function in cell adhesion and cell type specification. We discuss possible mechanisms by which it might function and review the emerging evidence for a close coupling between cell adhesion and cell type specification.

MeSH Terms
Amino Acid Sequence Animals Cell Adhesion/physiology Dictyostelium/cytology,physiology Disintegrins/chemistry,metabolism Invertebrate Hormones/metabolism Mammals Metalloendopeptidases/metabolism Molecular Sequence Data Movement/physiology Protozoan Proteins/chemistry,metabolism Sequence Alignment Sequence Homology, Amino Acid
Chemicals
Disintegrins Invertebrate Hormones Protozoan Proteins ornatin AmpA protein, Dictyostelium protozoan Metalloendopeptidases
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Blumberg Daphne D
Department of Biological Sciences, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA. [email protected]
Ho Hoa N
Petty Chere' L
Varney Timothy R
Gandham Srilatha
References (45)
45 references, click to expand
  1. Biochemistry and genetics of von Willebrand factor.
    Annu Rev Biochem. 1998;67:395-424 PMID: 9759493
  2. Factors controlling prespore cell differentiation in Dictyostelium discoideum: minute amounts of differentiation-inducing factor promote prespore cell differentiation.
    Differentiation. 1995 Dec;59(5):283-8 PMID: 8882813
  3. What have snakes taught us about integrins?
    Cell Mol Life Sci. 1998 Jun;54(6):527-40 PMID: 9676572
  4. Phg1p is a nine-transmembrane protein superfamily member involved in dictyostelium adhesion and phagocytosis.
    J Biol Chem. 2000 Nov 3;275(44):34287-92 PMID: 10944536
  5. A metalloprotease disintegrin that controls cell migration in Caenorhabditis elegans.
    Science. 2000 Jun 23;288(5474):2205-8 PMID: 10864868
  6. Expression, purification, and characterization of recombinant ornatin E, a potent glycoprotein IIb-IIIa antagonist.
    Protein Expr Purif. 1993 Aug;4(4):282-9 PMID: 8374297
  7. Metalloprotease-disintegrins: modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding.
    J Cell Sci. 1999 Nov;112 ( Pt 21):3603-17 PMID: 10523497
  8. The promoter of a gene encoding a novel Dictyostelium spore coat protein.
    Dev Biol. 1994 May;163(1):38-48 PMID: 8174786
  9. Structure, function and evolutionary relationship of proteins containing a disintegrin domain.
    Curr Opin Cell Biol. 1992 Oct;4(5):760-5 PMID: 1419054
  10. Patterns of cell movement within the Dictyostelium slug revealed by cell type-specific, surface labeling of living cells.
    Cell. 1994 Jun 3;77(5):687-99 PMID: 8205618
  11. Snake venom modulators of platelet adhesion receptors and their ligands.
    Toxicon. 2000 Jun;38(6):775-91 PMID: 10695965
  12. The ADAM gene family: surface proteins with adhesion and protease activity.
    Trends Genet. 2000 Feb;16(2):83-7 PMID: 10652535
  13. A novel Dictyostelium cell surface protein important for both cell adhesion and cell sorting.
    Development. 1998 Sep;125(17):3343-52 PMID: 9693138
  14. ADAM, a widely distributed and developmentally regulated gene family encoding membrane proteins with a disintegrin and metalloprotease domain.
    Dev Biol. 1995 May;169(1):378-83 PMID: 7750654
  15. Three-dimensional in vivo analysis of Dictyostelium mounds reveals directional sorting of prestalk cells and defines a role for the myosin II regulatory light chain in prestalk cell sorting and tip protrusion.
    Development. 2000 Jun;127(12):2715-28 PMID: 10821769
  16. A novel disintegrin domain protein affects early cell type specification and pattern formation in Dictyostelium.
    Development. 2002 May;129(10):2381-9 PMID: 11973270
  17. Discoidin domain receptors: structural relations and functional implications.
    FASEB J. 1999;13 Suppl:S77-82 PMID: 10352148
  18. Viper venom disintegrins and related molecules.
    Proc Soc Exp Biol Med. 1998 Nov;219(2):109-19 PMID: 9790167
  19. The membrane glycoprotein gp150 is encoded by the lagC gene and mediates cell-cell adhesion by heterophilic binding during Dictyostelium development.
    Dev Biol. 2000 Nov 15;227(2):734-45 PMID: 11071787
  20. Molecules on the sperm's route to fertilization.
    J Exp Zool. 1999 Oct 15;285(3):259-66 PMID: 10497325
  21. Evidence for positional differentiation of prestalk cells and for a morphogenetic gradient in Dictyostelium.
    Cell. 1995 Oct 6;83(1):91-9 PMID: 7553878
  22. ECM and cell surface proteolysis: regulating cellular ecology.
    Cell. 1997 Nov 14;91(4):439-42 PMID: 9390552
  23. A novel Dictyostelium gene encoding multiple repeats of adhesion inhibitor-like domains has effects on cell-cell and cell-substrate adhesion.
    Dev Biol. 2002 Mar 15;243(2):226-48 PMID: 11884033
  24. Metalloprotease-disintegrins: links to cell adhesion and cleavage of TNF alpha and Notch.
    Cell. 1997 Aug 22;90(4):589-92 PMID: 9288739
  25. Synthesis of the Ca(2+)-dependent cell adhesion molecule DdCAD-1 is regulated by multiple factors during Dictyostelium development.
    Differentiation. 1997 Aug;61(5):275-84 PMID: 9342838
  26. Xenopus kielin: A dorsalizing factor containing multiple chordin-type repeats secreted from the embryonic midline.
    Proc Natl Acad Sci U S A. 2000 May 9;97(10):5291-6 PMID: 10779551
  27. Surface glycoprotein, gp24, involved in early adhesion of Dictyostelium discoideum.
    Dev Biol. 1987 May;121(1):277-83 PMID: 3569662
  28. A family of cellular proteins related to snake venom disintegrins.
    Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2748-51 PMID: 8146185
  29. Structure and function of von Willebrand factor.
    Thromb Haemost. 1999 Aug;82(2):576-84 PMID: 10605754
  30. Ornatins: potent glycoprotein IIb-IIIa antagonists and platelet aggregation inhibitors from the leech Placobdella ornata.
    Eur J Biochem. 1991 Dec 18;202(3):1073-82 PMID: 1765068
  31. The many faces of metalloproteases: cell growth, invasion, angiogenesis and metastasis.
    Trends Cell Biol. 2001 Nov;11(11):S37-43 PMID: 11684441
  32. A novel prespore-cell-inducing factor in Dictyostelium discoideum induces cell division of prespore cells.
    Development. 1997 Jul;124(14):2781-7 PMID: 9226449
  33. A metalloprotease-disintegrin participating in myoblast fusion.
    Nature. 1995 Oct 19;377(6550):652-6 PMID: 7566181
  34. The different components of a multisubunit cell number-counting factor have both unique and overlapping functions.
    Development. 2002 Aug;129(15):3657-68 PMID: 12117815
  35. Integrins: versatility, modulation, and signaling in cell adhesion.
    Cell. 1992 Apr 3;69(1):11-25 PMID: 1555235
  36. Disintegrins and other naturally occurring antagonists of platelet fibrinogen receptors.
    Semin Hematol. 1994 Oct;31(4):289-300 PMID: 7831574
  37. A gene encoding a novel anti-adhesive protein is expressed in growing cells and restricted to anterior-like cells during development of Dictyostelium.
    Differentiation. 2002 Mar;70(1):23-35 PMID: 11963653
  38. Two distinct adhesion systems are responsible for EDTA-sensitive adhesion in Dictyostelium discoideum.
    Differentiation. 1993 Jul;53(3):139-47 PMID: 8405764
  39. Meltrin gamma(ADAM-9) mediates cellular adhesion through alpha(6)beta(1 )integrin, leading to a marked induction of fibroblast cell motility.
    J Cell Sci. 2000 Jun;113 ( Pt 12):2319-28 PMID: 10825303
  40. Characterization of the cell adhesion molecule gp24 in Dictyostelium discoideum. Mediation of cell-cell adhesion via a Ca(2+)-dependent mechanism.
    J Biol Chem. 1993 Nov 25;268(33):24902-9 PMID: 8227052
  41. Snake venom proteases affecting hemostasis and thrombosis.
    Biochim Biophys Acta. 2000 Mar 7;1477(1-2):146-56 PMID: 10708855
  42. Developmentally regulated, carbohydrate-binding protein in Dictyostelium discoideum.
    Proc Natl Acad Sci U S A. 1973 Sep;70(9):2554-7 PMID: 4517669
  43. Disruption of the gene encoding the cell adhesion molecule DdCAD-1 leads to aberrant cell sorting and cell-type proportioning during Dictyostelium development.
    Development. 2002 Aug;129(16):3839-50 PMID: 12135922
  44. A 130-kDa plasma membrane glycoprotein involved in Dictyostelium phagocytosis.
    Exp Cell Res. 1996 Sep 15;227(2):182-9 PMID: 8831554
  45. LagC is required for cell-cell interactions that are essential for cell-type differentiation in Dictyostelium.
    Genes Dev. 1994 Apr 15;8(8):948-58 PMID: 7926779
Article Info
Journal
Journal of muscle research and cell motility
Abbr.
J Muscle Res Cell Motil
ISSN
0142-4319
DOI
10.1023/a:1024440014857
Email
[email protected]
Published
2002-00-00
Pages
817-28
Language
English
Region
Netherlands
NLM ID
8006298
Subset
IM
Grants
NIGMS NIH HHS · R01GM56690 · United States
External Links
PubMed source DOI: 10.1023/a:1024440014857 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2