Abstract
A score based on the combination of the systemic inflammatory response and albumin hazards ratio (HR) 1.70, 95% CI 1.23 - 2.35, P=0.001) was comparable in prognostic value to that based on stage and performance status (HR 1.48, 95% CI 1.12 - 1.95, P=0.006) in patients with inoperable non-small-cell lung cancer. The former is simple to measure and well standardised.
MeSH Terms
Adenocarcinoma/blood,diagnosis
Albumins/analysis
Biomarkers, Tumor/analysis
C-Reactive Protein/analysis
Carcinoma, Non-Small-Cell Lung/blood,diagnosis
Carcinoma, Squamous Cell/blood,diagnosis
Female
Humans
Hypoalbuminemia/complications
Inflammation
Karnofsky Performance Status
Lung Neoplasms/blood,diagnosis
Male
Middle Aged
Neoplasm Staging
Prognosis
Prospective Studies
Retrospective Studies
Chemicals
Albumins
Biomarkers, Tumor
C-Reactive Protein
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Forrest L M
University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, UK.
McMillan D C
McArdle C S
Angerson W J
Dunlop D J
References (16)
16 references, click to expand
-
Prognostic factors in advanced gastrointestinal cancer patients with weight loss.
Nutr Cancer. 2000;37(1):36-40
PMID: 10965517
-
Weight loss and low body cell mass in males with lung cancer: relationship with systemic inflammation, acute-phase response, resting energy expenditure, and catabolic and anabolic hormones.
Clin Sci (Lond). 1999 Aug;97(2):215-23
PMID: 10409477
-
Prognostic value of performance status assessed by patients themselves, nurses, and oncologists in advanced non-small cell lung cancer.
Br J Cancer. 2001 Nov 30;85(11):1634-9
PMID: 11742480
-
The role of C-reactive protein as a prognostic indicator in advanced cancer.
Curr Oncol Rep. 2002 May;4(3):250-5
PMID: 11937016
-
The systemic inflammatory response, weight loss, performance status and survival in patients with inoperable non-small cell lung cancer.
Br J Cancer. 2002 Jul 29;87(3):264-7
PMID: 12177792
-
A prospective study of the impact of weight loss and the systemic inflammatory response on quality of life in patients with inoperable non-small cell lung cancer.
Lung Cancer. 2003 Jun;40(3):295-9
PMID: 12781428
-
A new international staging system for lung cancer.
Chest. 1986 Apr;89(4 Suppl):225S-233S
PMID: 3514171
-
Nitrite/nitrate and cytokine levels in bronchoalveolar lavage fluid of lung cancer patients.
Cancer. 1994 Sep 1;74(5):1546-51
PMID: 8062187
-
Serum levels of interleukin 6 in patients with lung cancer.
Br J Cancer. 1995 May;71(5):1095-8
PMID: 7734307
-
Increased resting energy expenditure and weight loss are related to a systemic inflammatory response in lung cancer patients.
J Clin Oncol. 1995 Oct;13(10):2600-5
PMID: 7595713
-
The relationship between weight loss and interleukin 6 in non-small-cell lung cancer.
Br J Cancer. 1996 Jun;73(12):1560-2
PMID: 8664130
-
Response to chemotherapy has predictive value for further survival of patients with advanced non-small cell lung cancer: 10 years experience of the European Lung Cancer Working Party.
Eur J Cancer. 1997 Dec;33(14):2326-32
PMID: 9616276
-
Longitudinal study of body cell mass depletion and the inflammatory response in cancer patients.
Nutr Cancer. 1998;31(2):101-5
PMID: 9770720
-
Is quality of life predictive of the survival of patients with advanced nonsmall cell lung carcinoma?
Cancer. 1999 Jan 15;85(2):333-40
PMID: 10023700
-
Cytokine levels (IL-6 and IFN-gamma), acute phase response and nutritional status as prognostic factors in lung cancer.
Cytokine. 1999 Jan;11(1):80-6
PMID: 10080883
-
Best supportive care in non-small cell lung cancer: is there a role for radiotherapy and chemotherapy?
Lung Cancer. 2001 Jun;32(3):213-26
PMID: 11390003