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PMID: 12975322 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

An essential role of Bmp4 in the atrioventricular septation of the mouse heart.

Genes & development ·Vol. 17 ·No. 19 ·2003-10-01 ·Pages 2362-7

Jiao K, Kulessa H, Tompkins K, Zhou Y, Batts L, Baldwin HS, Hogan BL

Abstract

Proper septation and valvulogenesis during cardiogenesis depend on interactions between the myocardium and the endocardium. By combining use of a hypomorphic Bone morphogenetic protein 4 (Bmp4) allele with conditional gene inactivation, we here identify Bmp4 as a signal from the myocardium directly mediating atrioventricular septation. Defects in this process cause one of the most common human congenital heart abnormalities, atrioventricular canal defect (AVCD). The spectrum of defects obtained through altering Bmp4 expression in the myocardium recapitulates the range of AVCDs diagnosed in patients, thus providing a useful genetic model with AVCD as the primary defect.

MeSH Terms
Animals Animals, Newborn Bone Morphogenetic Protein 4 Bone Morphogenetic Proteins/physiology Gene Expression Regulation, Developmental Heart/embryology,growth & development Heart Defects, Congenital/genetics,pathology Mice Mice, Mutant Strains Mice, Transgenic Myocytes, Cardiac/physiology Signal Transduction Transforming Growth Factor beta/genetics,metabolism Transforming Growth Factor beta2
Chemicals
BMP4 protein, human Bmp4 protein, mouse Bone Morphogenetic Protein 4 Bone Morphogenetic Proteins TGFB2 protein, human Transforming Growth Factor beta Transforming Growth Factor beta2
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Jiao Kai
Howard Hughes Medical Institute, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.
Kulessa Holger
Tompkins Kevin
Zhou Yingna
Batts Lorene
Baldwin H Scott
Hogan Brigid L M
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Article Info
Journal
Genes & development
Abbr.
Genes Dev
ISSN
0890-9369
DOI
10.1101/gad.1124803
Published
2003-10-01
Epub
2003-00-15
Pages
2362-7
Language
English
Region
United States
NLM ID
8711660
PMCID
PMC218073
Subset
IM
Grants
NHLBI NIH HHS · HL62177 · United States
External Links
PubMed source DOI: 10.1101/gad.1124803 PMC Full Text View journal details
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