Some observations concerning the mode of action of the antihistaminic drug "lergigan" (N(alpha-methyl-beta-dimethyl aminoethyl)phenothiazine hydrochloride) in motion sickness.

British journal of pharmacology and chemotherapy ·Vol. 8 ·No. 2 ·1953-06-00 ·Pages 181-6

GERNANDT BE, SCHMITERLOW CG

Abstract

暂无摘要

Keywords

ANTIHISTAMINICS/effects BLOOD PRESSURE/physiology NERVES ACOUSTIC/physiology PHENOTHIAZINE/derivatives

MeSH Terms

Blood Pressure/physiology Blood Pressure Determination Cochlear Nerve/physiology Histamine H1 Antagonists/pharmacology Humans Motion Sickness Phenothiazines/analogs & derivatives

Chemicals

Histamine H1 Antagonists Phenothiazines phenothiazine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

GERNANDT B E

SCHMITERLOW C G

References (8)

8 references, click to expand

Evaluation of some drugs in motion sickness.
J Aviat Med. 1950 Oct;21(5):424-9 PMID: 14778797
A central action of some antihistamines. Correction of forced circling movements and of seizure brain waves produced by the intracarotid injection of diisopropyl fluorophosphate (DFP).
Am J Psychiatry. 1950 Nov;107(5):367-72 PMID: 14783213
Do dorsal root fibers convey centrally induced vasodilator impulses?
Acta Physiol Scand. 1950 Nov;21(2-3):145-58 PMID: 14856765
Are parasympathetic vasodilator fibers involved in depressor reflexes elicited from the baroceptor regions?
Acta Physiol Scand. 1951 Jul 30;23(1):64-77 PMID: 14856795
Further studies on the effectiveness of various drugs against airsickness.
J Aviat Med. 1951 Dec;22(6):535-9 PMID: 14897805
The effectiveness of various drugs for the prophylaxis of seasickness.
Am J Med. 1952 Apr;12(4):433-9 PMID: 14923671
Pressor responses to electrical stimulation of the carotid sinus nerve in cats.
J Physiol. 1949 Sep;109(3-4):259-71 PMID: 15395011
The influence of diphenhydramine HCl (benadryl) on apomorphine-induced emesis in dogs.
J Pharmacol Exp Ther. 1950 Mar;98(3):245-50 PMID: 15428983

Article Info

Journal

British journal of pharmacology and chemotherapy

Abbr.

Br J Pharmacol Chemother

ISSN

0366-0826

DOI

10.1111/j.1476-5381.1953.tb00775.x

Published

1953-06-00

Pages

181-6

Language

English

Region

England

NLM ID

0154627

PMCID

PMC1509319

Subset

External Links

PubMed source DOI: 10.1111/j.1476-5381.1953.tb00775.x PMC Full Text

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Some observations concerning the mode of action of the antihistaminic drug "lergigan" (N(alpha-methyl-beta-dimethyl aminoethyl)phenothiazine hydrochloride) in motion sickness.

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