The effect of manipulation of reticuloendothelial system activity on glomerular deposition of aggregated protein and immune complexes in two different strains of mice.

British journal of experimental pathology ·Vol. 56 ·No. 6 ·1975-12-00 ·Pages 523-9

Ford PM

Abstract

Glomerular uptake of intravenously administered aggregated albumen or immune complexes in mice appears to be inversely related to the activity of the reticuloendothelial system (RES). Stimulation of RES activity diminishes the amount of material appearing in the glomerulus whereas RES blockade enhances glomerular uptake. The possible relevance of these observations to experimental models of immune complex disease is discussed.

MeSH Terms

Anaphylaxis Animals Antigen-Antibody Complex Carbon/metabolism Immune Complex Diseases/etiology Kidney Glomerulus/immunology,metabolism Macrophages/immunology Mice Mice, Inbred DBA Mice, Inbred Strains Mononuclear Phagocyte System/drug effects,metabolism Serum Albumin, Bovine/metabolism

Chemicals

Antigen-Antibody Complex Serum Albumin, Bovine Carbon

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Ford P M

References (13)

13 references, click to expand

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Passive serum sickness in the mouse: effect of interstrain differences on glomerular deposition of immune complexes.
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Quantitative study of the granulopectic activity of the reticulo-endothelial system. II. A study of the kinetics of the R. E. S. in relation to the dose of carbon injected; relationship between the weight of the organs and their activity.
Br J Exp Pathol. 1953 Aug;34(4):441-57 PMID: 13093915
The histamine and serotonin content of the platelets and polymorphonuclear leucocytes of various species.
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Article Info

Journal

British journal of experimental pathology

Abbr.

Br J Exp Pathol

ISSN

0007-1021

Published

1975-12-00

Pages

523-9

Language

English

Region

England

NLM ID

0372543

PMCID

PMC2072791

Subset

External Links

PubMed source PMC Full Text View journal details

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The effect of manipulation of reticuloendothelial system activity on glomerular deposition of aggregated protein and immune complexes in two different strains of mice.

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