A possible role for nonsense suppression in the synthesis of a human cytomegalovirus 58-kDa virion protein.

Virology ·Vol. 186 ·No. 1 ·1992-01-00 ·Pages 309-12

Lahijani RS, Otteson EW, St Jeor SC

Abstract

A 1.6-kb late mRNA originating from the HindIII R fragment of human cytomegalovirus (HCMV) encodes a 58-kDa virion phosphoprotein. Data presented support the hypothesis that this protein may be synthesized via the translational readthrough of an opal termination codon separating two open reading frames located in tandem. To our knowledge this is the first report of nonsense suppression as a means of regulating gene expression in HCMV.

MeSH Terms

Amino Acid Sequence Base Sequence Cytomegalovirus/genetics DNA, Viral/genetics Gene Expression Regulation, Viral Genes, Suppressor Genetic Code Glycoproteins/genetics Molecular Sequence Data Phosphoproteins/genetics Protein Biosynthesis RNA, Messenger/genetics RNA, Viral/genetics Restriction Mapping Viral Proteins/genetics

Chemicals

DNA, Viral Glycoproteins Phosphoproteins RNA, Messenger RNA, Viral Viral Proteins

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Lahijani R S

Department of Microbiology, University of Nevada, Reno 89557.

Otteson E W

St Jeor S C

Article Info

Journal

Virology

Abbr.

Virology

ISSN

0042-6822

DOI

10.1016/0042-6822(92)90087-6

Published

1992-01-00

Pages

309-12

Language

English

Region

United States

NLM ID

0110674

Subset

External Links

PubMed source DOI: 10.1016/0042-6822(92)90087-6 View journal details

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A possible role for nonsense suppression in the synthesis of a human cytomegalovirus 58-kDa virion protein.

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