Home LiteratureArticle Details
PMID: 13094499 Published · ppublish English Journal Article

The influenza virus: its morphology, immunology, and kinetics of multiplication.

Bulletin of the World Health Organization ·Vol. 8 ·No. 5-6 ·1953-00-00 ·Pages 647-60

von MAGNUS P

Abstract

The morphology of influenza virus is described, and the properties of its two components, the elementary body and the soluble substance, differentiated. The relationship between the filamentous and spherical structures observed in the infected allantoic fluid is still obscure, but the filaments are thought to represent either a form of influenza virus or a stage in its multiplication.The antigenic constitution of A and B viruses is discussed and variations in the pattern of individual strains over the past two decades described. The author outlines his speculations on the origin and mechanism of these variations. Other differences in serological behaviour, such as non-specific inhibition and the avidity effect, are discussed.The results of experimental investigation, with various animal hosts, of the kinetics of influenza virus multiplication are reviewed, and the effects of such factors as incubation temperature and concentration of the seed virus considered. The bearing of these studies of enzymatic virus/host-cell interactions on the chemotherapeutic control of influenza is emphasized.

Keywords
INFLUENZA VIRUSES
MeSH Terms
Animals Humans Influenza, Human Kinetics Orthomyxoviridae
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
von MAGNUS P
References (56)
56 references, click to expand
  1. The multiplication of complement-fixing antigen and red-cell agglutinin in the chorio-allantoic membrane of fertile eggs inoculated with influenza virus.
    J Pathol Bacteriol. 1952 Apr;64(2):419-23 PMID: 14946664
  2. Strain-specific elements in influenza antigens.
    J Exp Med. 1952 Dec;96(6):589-603 PMID: 13022853
  3. The investigation of influenza and related viruses in the electron microscope, by a new technique.
    J Gen Microbiol. 1949 May;3(2):298-311 PMID: 18149943
  4. Inhibitors of influenza virus haemagglutination in normal animal sera.
    Bull World Health Organ. 1952;6(4):467-72 PMID: 12997989
  5. An interpretation of the significance of influenza virus variation for the development of an effective vaccine.
    Bull N Y Acad Med. 1952 Nov;28(11):748-65 PMID: 12987937
  6. Structure of the influenza virus; the relation between biological activity and chemical structure of virus fractions.
    J Hyg (Lond). 1952 Jun;50(2):229-45 PMID: 14938535
  7. The role of l-methionine in virus propagation.
    J Exp Med. 1951 Apr 1;93(4):337-43 PMID: 14824406
  8. THE SIZE OF INFLUENZA VIRUS.
    J Exp Med. 1944 Mar 1;79(3):267-83 PMID: 19871369
  9. BIOPHYSICAL PROPERTIES OF PREPARATIONS OF PR8 INFLUENZA VIRUS.
    J Exp Med. 1944 Dec 1;80(6):531-48 PMID: 19871435
  10. The spread of influenza; evidence from 1950-1951.
    Br Med J. 1951 Oct 20;2(4737):921-7 PMID: 14869766
  11. A pattern of antigen variation.
    Fed Proc. 1952 Sep;11(3):798-803 PMID: 12980134
  12. System for measuring and designating antigenic components of influenza viruses with analyses of recently isolated strains.
    Proc Soc Exp Biol Med. 1951 Oct;78(1):208-15 PMID: 14891969
  13. Interference phenomena between animal viruses; a review.
    J Immunol. 1950 Mar;64(3):203-36 PMID: 15412251
  14. Electron microscopy of chick embryo membrane infected with PR-8 influenza.
    Nature. 1951 Oct 13;168(4276):651-2 PMID: 14882301
  15. Observations with the electron microscope on cells of the chick chorio-allantoic membrane infected with influenza virus.
    J Exp Med. 1952 Mar;95(3):259-68 PMID: 14927791
  16. Influenza virus in sectioned tissues.
    Proc Soc Exp Biol Med. 1950 Oct;75(1):290-3 PMID: 14797810
  17. Antigenic analysis of influenza B strains isolated in 1952.
    Bull World Health Organ. 1952;6(4):481-5 PMID: 12997991
  18. The use of V. cholerae filtrates in the destruction of non-specific inhibitor in ferret sera.
    Br J Exp Pathol. 1951 Aug;32(4):325-35 PMID: 14886492
  19. Influenza A viruses; laboratory studies, with special reference to European outbreak of 1950-1.
    Bull World Health Organ. 1952;6(3):287-315 PMID: 12988024
  20. CENTRIFUGATION AND ULTRAFILTRATION STUDIES ON ALLANTOIC FLUID PREPARATIONS OF INFLUENZA VIRUS.
    J Exp Med. 1944 Mar 1;79(3):301-17 PMID: 19871372
  21. Further studies on antigenic variation of influenza A virus.
    Proc Soc Exp Biol Med. 1952 Jun;80(2):212-4 PMID: 14949001
  22. The serological comparison of strains of influenza virus.
    J Gen Microbiol. 1949 Jan;3(1):97-111 PMID: 18127017
  23. STUDIES ON INFLUENZA VIRUS : THE COMPLEMENT-FIXING ANTIGEN OF INFLUENZA A AND SWINE INFLUENZA VIRUSES.
    J Exp Med. 1941 Apr 30;73(5):581-99 PMID: 19871098
  24. STUDIES ON THE COMPLEMENT FIXATION ANTIGENS OF INFLUENZA VIRUSES TYPES A AND B.
    J Exp Med. 1946 Mar 31;83(4):259-79 PMID: 19871529
  25. Incomplete growth cycle of influenza virus in mouse brain.
    Proc Soc Exp Biol Med. 1950 Jul;74(3):541-8 PMID: 15440881
  26. THE IMMUNOLOGICAL RESPONSE TO INFLUENZA VIRUS INFECTION AS MEASURED BY THE COMPLEMENT FIXATION TEST : RELATION OF THE COMPLEMENT-FIXING ANTIGEN TO THE VIRUS PARTICLE.
    J Exp Med. 1943 Nov 1;78(5):347-66 PMID: 19871335
  27. Growth-cycle of influenza virus.
    Nature. 1949 Jul 30;164(4161):189 PMID: 18135937
  28. Study of infectivity and hemagglutination of influenza virus in deembryonated eggs.
    J Immunol. 1950 Nov;65(5):571-83 PMID: 14794922
  29. Adventures among viruses; epidemic influenza.
    N Engl J Med. 1950 Feb 9;242(6):197-203 PMID: 15403337
  30. Studies on the antigenic behaviour of egg- and egg-mouse-egg-lines of strains of influenza virus, with the aid of the haemagglutination-inhibition test.
    Antonie Van Leeuwenhoek. 1952;18(2):139-52 PMID: 14944171
  31. Quantitative aspects of influenza virus multiplication.
    J Immunol. 1952 Aug;69(2):155-81 PMID: 14946411
  32. Persistent antigenic variation of influenza A viruses after incomplete neutralization in ovo with heterologous immune serum.
    J Exp Med. 1950 Nov 1;92(5):441-62 PMID: 14778924
  33. CULTIVATION OF HUMAN INFLUENZA VIRUS IN AN ARTIFICIAL MEDIUM.
    Science. 1935 Oct 11;82(2128):353-4 PMID: 17733215
  34. Studies of influenza A (pr8) infected tissue cultures by electron microscopy.
    Proc Soc Exp Biol Med. 1950 Apr;73(4):596-9 PMID: 15417609
  35. Studies on host-virus interactions in the chick embryo-influenza virus system; development of infectivity, hemagglutination, and complement fixation activities during the first infectious cycle.
    J Exp Med. 1949 Jul;90(1):23-37 PMID: 18152337
  36. THE DEMONSTRATION OF ONE-STEP GROWTH CURVES OF INFLUENZA VIRUSES THROUGH THE BLOCKING EFFECT OF IRRADIATED VIRUS ON FURTHER INFECTION.
    J Exp Med. 1947 Oct 31;86(5):423-37 PMID: 19871688
  37. The relation of the Krebs cycle to viral synthesis. II. The effect of sodium fluoroacetate on the propagation of influenza virus in mice.
    J Exp Med. 1951 Jun;93(6):635-42 PMID: 14832407
  38. Concerning the relation of the Krebs cycle to virus propagation.
    J Biol Chem. 1951 Mar;189(1):421-8 PMID: 14832255
  39. Experience with Vaccination Against Influenza in the Spring of 1947: A Preliminary Report.
    Am J Public Health Nations Health. 1947 Aug;37(8):1013-6 PMID: 18016577
  40. Studies on host-virus interactions in the chick embryo-influenza virus system. IV. The role of inhibitors of hemagglutination in the evaluation of viral multiplication.
    J Exp Med. 1951 Oct;94(4):269-89 PMID: 14888812
  41. QUALITATIVE DIFFERENCES IN THE ANTIGENIC COMPOSITION OF INFLUENZA A VIRUS STRAINS.
    J Exp Med. 1944 Jun 1;79(6):633-47 PMID: 19871392
  42. A STUDY OF CONDITIONS FOR THE OPTIMUM PRODUCTION OF PR8 INFLUENZA VIRUS IN CHICK EMBRYOS.
    J Exp Med. 1944 Feb 1;79(2):173-83 PMID: 19871361
  43. EXPERIMENTAL INFECTION WITH INFLUENZA A VIRUS IN MICE : THE INCREASE IN INTRAPULMONARY VIRUS AFTER INOCULATION AND THE INFLUENCE OF VARIOUS FACTORS THEREON.
    J Exp Med. 1941 Jan 1;73(1):43-55 PMID: 19871064
  44. Identification of another epidemic respiratory disease.
    Science. 1950 Oct 27;112(2913):495-7 PMID: 14787444
  45. STUDIES ON THE MECHANISM OF ADAPTATION OF INFLUENZA VIRUS TO MICE.
    J Exp Med. 1947 Oct 31;86(5):357-66 PMID: 19871683
  46. A comparison of influenza complement fixation antigens derived from allantoic fluids and membranes.
    J Immunol. 1950 Aug;65(2):229-44 PMID: 15437002
  47. A comparison of the growth curves of adapted and unadapted lines of influenza virus.
    J Exp Med. 1951 Feb;93(2):129-37 PMID: 14803637
  48. Comparison of the antigenic patterns of influenza A virus strains determined by in ovo neutralization and hemagglutination-inhibition.
    J Immunol. 1952 Sep;69(3):343-56 PMID: 13000145
  49. The influence of treating ferret influenza antisera with enzymes of crude filtrate of Vibrio cholerae on the titre of the antibodies.
    Antonie Van Leeuwenhoek. 1952;18(2):128-30 PMID: 14944169
  50. Antigenic analysis of influenza viruses by the haemagglutination-inhibition technique; results of use of different animal sera.
    Bull World Health Organ. 1952;6(4):473-80 PMID: 12997990
  51. Studies of the antigenic composition of influenza B viruses.
    Bull World Health Organ. 1952;5(2):149-63 PMID: 14925819
  52. Propagation of the PR8 strain of influenza A virus in chick embryos. II. The formation of incomplete virus following inoculation of large doses of seed virus.
    Acta Pathol Microbiol Scand. 1951;28(3):278-93 PMID: 14856732
  53. Effect of glucose on the growth of influenza virus in deembryonated eggs and tissue cultures.
    J Immunol. 1952 Sep;69(3):321-9 PMID: 13000143
  54. THE QUANTITATIVE DETERMINATION OF INFLUENZA VIRUS AND ANTIBODIES BY MEANS OF RED CELL AGGLUTINATION.
    J Exp Med. 1942 Jan 1;75(1):49-64 PMID: 19871167
  55. Filamentous forms associated with newly isolated influenza virus.
    Lancet. 1949 Apr 9;1(6554):602 PMID: 18124993
  56. STUDIES OF ANTIGENIC DIFFERENCES AMONG STRAINS OF INFLUENZA A BY MEANS OF RED CELL AGGLUTINATION.
    J Exp Med. 1943 Nov 1;78(5):407-23 PMID: 19871338
Article Info
Journal
Bulletin of the World Health Organization
Abbr.
Bull World Health Organ
ISSN
0042-9686
Published
1953-00-00
Pages
647-60
Language
English
Region
Switzerland
NLM ID
7507052
PMCID
PMC2554196
Subset
OM
External Links
PubMed source PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2