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PMID: 1309649 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

A family of metabotropic glutamate receptors.

Neuron ·Vol. 8 ·No. 1 ·1992-01-00 ·Pages 169-79

Tanabe Y, Masu M, Ishii T, Shigemoto R, Nakanishi S

Abstract

Three cDNA clones, mGluR2, mGluR3, and mGluR4, were isolated from a rat brain cDNA library by cross-hybridization with the cDNA for a metabotropic glutamate receptor (mGluR1). The cloned receptors show considerable sequence similarity with mGluR1 and possess a large extracellular domain preceding the seven putative membrane-spanning segments. mGluR2 is expressed in some particular neuronal cells different from those expressing mGluR1 and mediates an efficient inhibition of forskolin-stimulated cAMP formation in cDNA-transfected cells. The mGluRs thus form a novel family of G protein-coupled receptors that differ in their signal transduction and expression patterns.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Brain Chemistry CHO Cells Cell Membrane/chemistry Cerebellum/chemistry Cerebral Cortex/chemistry Cloning, Molecular Colforsin/pharmacology Cricetinae Cyclic AMP/biosynthesis DNA/chemistry,isolation & purification Gene Expression Molecular Sequence Data Nucleic Acid Hybridization Olfactory Bulb/chemistry RNA, Messenger/analysis Rats Receptors, Glutamate Receptors, Neurotransmitter/chemistry,genetics Signal Transduction Tissue Distribution Transfection
Chemicals
RNA, Messenger Receptors, Glutamate Receptors, Neurotransmitter Colforsin DNA Cyclic AMP
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Tanabe Y
Institute for Immunology, Kyoto University Faculty of Medicine, Japan.
Masu M
Ishii T
Shigemoto R
Nakanishi S
Article Info
Journal
Neuron
Abbr.
Neuron
ISSN
0896-6273
DOI
10.1016/0896-6273(92)90118-w
Published
1992-01-00
Pages
169-79
Language
English
Region
United States
NLM ID
8809320
Subset
IM
External Links
PubMed source DOI: 10.1016/0896-6273(92)90118-w View journal details
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