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PMID: 1315535 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Sugar modified oligonucleotides: synthesis, nuclease resistance and base pairing of oligodeoxynucleotides containing 1-(4'-thio-beta-D-ribofuranosyl)-thymine.

Biochemical and biophysical research communications ·Vol. 184 ·No. 2 ·1992-04-30 ·Pages 797-803

Bellon L, Morvan F, Barascut JL, Imbach JL

Abstract

XdT12 and dT5XdT6, where X is 1-(4'-thio-beta-d-ribofuranosyl)-thymine, were synthesized. The first oligonucleotide presents a better stability against calf spleen phosphodiesterase than natural dT12. The second one hybridizes with complementary sequence. However the X:A base pairing stability is lower than natural T:A one.

MeSH Terms

Animals Base Composition Cattle Drug Stability Indicators and Reagents Magnetic Resonance Spectroscopy Nucleic Acid Denaturation Oligonucleotides/chemical synthesis,metabolism Phosphoric Diester Hydrolases/metabolism Spleen/enzymology Substrate Specificity Thionucleosides Thymidine/analogs & derivatives

Chemicals

Indicators and Reagents Oligonucleotides Thionucleosides 1-(4'-thio-beta-ribofuranosyl)thymine Phosphoric Diester Hydrolases Thymidine

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Bellon L

Université de Montpellier II Sciences, URA 488 du CNRS, France.

Morvan F

Barascut J L

Imbach J L

Article Info

Journal

Biochemical and biophysical research communications

Abbr.

Biochem Biophys Res Commun

ISSN

0006-291X

DOI

10.1016/0006-291x(92)90660-d

Published

1992-04-30

Pages

797-803

Language

English

Region

United States

NLM ID

0372516

Subset

External Links

PubMed source DOI: 10.1016/0006-291x(92)90660-d View journal details

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Sugar modified oligonucleotides: synthesis, nuclease resistance and base pairing of oligodeoxynucleotides containing 1-(4'-thio-beta-D-ribofuranosyl)-thymine.

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