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PMID: 1316492 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

New member of the multigene family of complement control proteins in herpesvirus saimiri.

Journal of virology ·Vol. 66 ·No. 6 ·1992-06-00 ·Pages 3937-40

Albrecht JC, Fleckenstein B

Abstract

A number of glycoproteins are regulators of the complement cascade and prevent damage to cells by inappropriate activation of complement. In humans, all of them are encoded by a multigene family on chromosome I and share a characteristic structural feature, the short consensus repeats of about 61 amino acids with a constant framework of cysteine, proline, and tryptophan. We found the gene for glycoproteins of analogous structure in herpesvirus saimiri, a T-lymphotropic tumor virus of New World primates. Unspliced transcripts code for a membrane-bound 65- to 75-kDa virion surface component, while spliced mRNA instructs a secreted glycoprotein of 47 to 53 kDa. Expression of complement control proteins suggests a novel mechanism of counteracting host immune defense to prevent elimination of a virus that is capable of persisting in circulating lymphocytes.

MeSH Terms
Amino Acid Sequence Antigens, CD/genetics Base Sequence Complement System Proteins/metabolism Consensus Sequence Herpesvirus 2, Saimiriine/genetics Host-Parasite Interactions/genetics Membrane Glycoproteins/genetics Molecular Sequence Data Multigene Family/genetics Repetitive Sequences, Nucleic Acid Sequence Homology, Nucleic Acid Viral Proteins/genetics
Chemicals
Antigens, CD Membrane Glycoproteins Viral Proteins herpesvirus saimiri protein, Saimiriine herpesvirus 2 Complement System Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Albrecht J C
Institut für Klinische und Molekulare Virologie Friedrich-Alexander Universität Erlangen-Nürnberg, Germany.
Fleckenstein B
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.66.6.3937-3940.1992
Published
1992-06-00
Pages
3937-40
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC241185
Subset
IM
Databases
GENBANK
X60283
External Links
PubMed source DOI: 10.1128/JVI.66.6.3937-3940.1992 PMC Full Text View journal details
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