Effects of cortisone on rat liver mitochondria.

The Journal of biophysical and biochemical cytology ·Vol. 1 ·No. 3 ·1955-05-25 ·Pages 237-44

LOWE CU, MACKINNEY D, SARKARIA D

Abstract

Experiments were designed to determine the effects of parenteral administration of cortisone on mitochondrial numbers of rat liver cells. Observations were made in three ways: (1) after osmic acid fixation and appropriate stain, (2) by phase microscopy on intact cells, (3) by actual enumeration of mitochondria and nuclei to provide data on mitochondria per cell. The results of the experiments indicate that the mitochondria per cell are significantly reduced under the conditions used. Each experimental approach provided similar data, and each tended to support the results obtained from the others.

Keywords

CORTISONE/effects LIVER/effect of drugs on MITOCHONDRIA

MeSH Terms

Animals Cortisone/pharmacology Liver/drug effects Microscopy Mitochondria Mitochondria, Liver Pharmaceutical Preparations Rats

Chemicals

Pharmaceutical Preparations Cortisone

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

LOWE C U

MACKINNEY D

SARKARIA D

References (14)

14 references, click to expand

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Effect of cortisone administration on intracellular composition of rat liver.
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Oxidation and phosphorylation in liver mitochondria lacking polymerized ribonucleic acid.
J Biophys Biochem Cytol. 1955 Jan;1(1):89-92 PMID: 14381430
Cellular changes in the chick chorio-allantoic membrane infected with herpes simplex and vaccinia; a study with thin sections for the electron microscope.
Bull Johns Hopkins Hosp. 1950 Dec;87(6):511-47 PMID: 14783718
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C R Hebd Seances Acad Sci. 1951 Oct 22;233(17):990-2 PMID: 14896542
Cytoplasmic changes in hepatic parenchyma of mice during starvation and carbon tetrachloride-induced injury.
Anat Rec. 1951 Dec;111(4):629-51 PMID: 14903574
Effect of cortisone administration upon nucleic acid composition of rabbit liver.
Proc Soc Exp Biol Med. 1951 Dec;78(3):818-24 PMID: 14912043
A study of binucleate cell counts in resting and regenerating rat liver employing a mechanical method for the separation of liver cells.
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Morphological and chemical changes elicited in the liver of the rabbit by cortisone and desoxycorticosterone acetate.
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Article Info

Journal

The Journal of biophysical and biochemical cytology

Abbr.

J Biophys Biochem Cytol

ISSN

0095-9901

DOI

10.1083/jcb.1.3.237

Published

1955-05-25

Pages

237-44

Language

English

Region

United States

NLM ID

17840020R

PMCID

PMC2223815

Subset

External Links

PubMed source DOI: 10.1083/jcb.1.3.237 PMC Full Text

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