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PMID: 1325605 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Gene-environment interactions in atherosclerosis.

Molecular and cellular biochemistry ·Vol. 113 ·No. 2 ·1992-08-18 ·Pages 177-86

Hegele RA

Abstract

The importance of environment and genetics working together to shape an individual's risk for atherosclerosis seems intuitively obvious. However, it is only recently that research strategies have begun to evolve that attempt to answer questions related to apportionment of risk that is due to specific environmental and genetic factors. These factors may impact upon risk either singly or, more likely, through a complex interaction that affects the metabolic history of the whole organism. Because the genetic bases of lipid and lipoprotein metabolism have been well-studied, and because of the epidemiologic and pathobiochemical associations between genetic disorders of lipid metabolism and atherosclerosis, researchers have searched for gene-environment interactions within animal and human systems in which the phenotype is defined by some index of lipoprotein metabolism. From work done in the lipoprotein area to this point a clear case can be made for: 1) the genetic influence over the phenotypic response to an environmental stimulus; 2) the environmental modulation of the phenotypic expression of severe genetic defects. In the realm of gene-environment interactions that affect lipoprotein phenotype, diet is the best-studied environmental factor.

MeSH Terms
Apolipoproteins/genetics Arteriosclerosis/etiology,genetics Diet Environment Genetic Variation Humans Receptors, Cell Surface/genetics
Chemicals
Apolipoproteins Receptors, Cell Surface
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Hegele R A
University of Toronto, Canada.
References (44)
44 references, click to expand
  1. An apolipoprotein CII mutation, CIILys19----Thr' identified in patients with hyperlipidemia.
    Dis Markers. 1991 Mar-Apr;9(2):73-80 PMID: 1782747
  2. Study of the genetic transmission of hypercholesterolemia and hypertriglyceridemia in a 195 member kindred.
    Ann Hum Genet. 1975 Jul;39(1):67-87 PMID: 1180488
  3. Ath-1, a gene determining atherosclerosis susceptibility and high density lipoprotein levels in mice.
    Proc Natl Acad Sci U S A. 1987 Jun;84(11):3763-7 PMID: 3473481
  4. Increased high-density lipoprotein levels caused by a common cholesteryl-ester transfer protein gene mutation.
    N Engl J Med. 1990 Nov 1;323(18):1234-8 PMID: 2215607
  5. Cholesterol in the prediction of atherosclerotic disease. New perspectives based on the Framingham study.
    Ann Intern Med. 1979 Jan;90(1):85-91 PMID: 217290
  6. Phenotypic expression of heterozygous lipoprotein lipase deficiency in the extended pedigree of a proband homozygous for a missense mutation.
    J Clin Invest. 1990 Sep;86(3):735-50 PMID: 2394828
  7. A survey of 246 suggested coronary risk factors.
    Atherosclerosis. 1981 Aug-Sep;40(1):1-52 PMID: 7025843
  8. A hepatic lipase gene mutation associated with heritable lipolytic deficiency.
    J Clin Endocrinol Metab. 1991 Mar;72(3):730-2 PMID: 1671786
  9. Genetic basis of lipoprotein disorders.
    J Clin Invest. 1989 Aug;84(2):373-80 PMID: 2668331
  10. Effects of diet on lipoprotein metabolism.
    Annu Rev Nutr. 1985;5:195-212 PMID: 3896268
  11. Genetic variation in mouse apolipoprotein A-IV due to insertion and deletion in a region of tandem repeats.
    J Biol Chem. 1991 Jul 5;266(19):12715-21 PMID: 1648102
  12. "Variability gene" effect of cholesteryl ester transfer protein (CETP) genes.
    Clin Genet. 1989 Jun;35(6):437-45 PMID: 2567644
  13. Apolipoprotein genetic variation in the assessment of atherosclerosis susceptibility.
    Genet Epidemiol. 1987;4(3):163-84 PMID: 2886398
  14. Apolipoprotein E polymorphism and plasma cholesterol response to probucol.
    Metabolism. 1987 Aug;36(8):743-7 PMID: 3600286
  15. Hyperlipidemia in coronary heart disease. 3. Evaluation of lipoprotein phenotypes of 156 genetically defined survivors of myocardial infarction.
    J Clin Invest. 1973 Jul;52(7):1569-77 PMID: 4352458
  16. Epidemiologic studies of coronary heart disease and stroke in Japanese men living in Japan, Hawaii and California: demographic, physical, dietary and biochemical characteristics.
    J Chronic Dis. 1974 Sep;27(7-8):345-64 PMID: 4436426
  17. Diet-induced hypercholesterolemia in mice: prevention by overexpression of LDL receptors.
    Science. 1990 Nov 30;250(4985):1273-5 PMID: 2244210
  18. Smoking and reverse cholesterol transport: evidence for gene-environment interaction.
    Clin Genet. 1989 Oct;36(4):266-8 PMID: 2509115
  19. Plasma high density lipoproteins. Metabolism and relationship to atherogenesis.
    J Clin Invest. 1990 Aug;86(2):379-84 PMID: 2200802
  20. Molecular biology in arteriosclerosis research.
    Arteriosclerosis. 1985 May-Jun;5(3):213-27 PMID: 3888164
  21. Genetic factors controlling structure and expression of apolipoproteins B and E in mice.
    J Biol Chem. 1987 Jun 5;262(16):7594-604 PMID: 3034900
  22. DNA polymorphism at the locus for human cholesteryl ester transfer protein (CETP) is associated with high density lipoprotein cholesterol and apolipoprotein levels.
    Clin Genet. 1989 Jan;35(1):49-56 PMID: 2564326
  23. Serum cholesterol, lipoproteins, and the risk of coronary heart disease. The Framingham study.
    Ann Intern Med. 1971 Jan;74(1):1-12 PMID: 5539274
  24. Hyperlipidemia in coronary heart disease. I. Lipid levels in 500 survivors of myocardial infarction.
    J Clin Invest. 1973 Jul;52(7):1533-43 PMID: 4718952
  25. Effects of cholesterol and fat modification of self-selected diets on serum lipids and their specific fatty acids in normocholesterolemic and hypercholesterolemic humans.
    J Am Coll Nutr. 1991 Apr;10(2):93-106 PMID: 2030259
  26. Genetic analysis of apolipoprotein A-I in two dietary environments.
    Am J Hum Genet. 1990 Sep;47(3):414-28 PMID: 2118306
  27. Inference of a molecular defect of apolipoprotein B in hypobetalipoproteinemia by linkage analysis in a large kindred.
    J Clin Invest. 1988 Sep;82(3):847-51 PMID: 2901434
  28. Atherogenic hyperlipoproteinemia. The cellular and molecular biology of plasma lipoproteins altered by dietary fat and cholesterol.
    Med Clin North Am. 1982 Mar;66(2):375-402 PMID: 7040843
  29. Molecular basis of lipid transfer protein deficiency in a family with increased high-density lipoproteins.
    Nature. 1989 Nov 23;342(6248):448-51 PMID: 2586614
  30. Clinical application of deoxyribonucleic acid markers in a Utah family with hypercholesterolemia.
    Am J Cardiol. 1989 Jan 1;63(1):109-12 PMID: 2909140
  31. Type III dyslipoproteinemia in patients heterozygous for familial hypercholesterolemia and apolipoprotein E2. Evidence for a gene-gene interaction.
    Arterioscler Thromb. 1991 Sep-Oct;11(5):1137-46 PMID: 1680391
  32. Inheritance of apolipoprotein C-II deficiency with hypertriglyceridemia and pancreatitis.
    N Engl J Med. 1978 Dec 28;299(26):1421-4 PMID: 213719
  33. Hyperlipidemia in coronary heart disease. II. Genetic analysis of lipid levels in 176 families and delineation of a new inherited disorder, combined hyperlipidemia.
    J Clin Invest. 1973 Jul;52(7):1544-68 PMID: 4718953
  34. Population-based lipoprotein lipid reference values for pregnant women compared to nonpregnant women classified by sex hormone usage.
    Am J Obstet Gynecol. 1982 Jul 15;143(6):626-37 PMID: 7091235
  35. The LDL-receptor-related protein, LRP, is an apolipoprotein E-binding protein.
    Nature. 1989 Sep 14;341(6238):162-4 PMID: 2779654
  36. The effect of genetic determinants of low density lipoprotein levels on lipoprotein (a).
    Clin Invest Med. 1991 Apr;14(2):146-52 PMID: 1829402
  37. Dietary fat clearance in normal subjects is regulated by genetic variation in apolipoprotein E.
    J Clin Invest. 1987 Dec;80(6):1571-7 PMID: 3479440
  38. Genetic factors affecting blood lipoproteins: the candidate gene approach.
    J Lipid Res. 1988 Apr;29(4):397-429 PMID: 3292686
  39. Genetic and environmental contributions to cholesterol and its subfractions in 11-year-old twins. The Medical College of Virginia Twin Study.
    Arterioscler Thromb. 1991 Jul-Aug;11(4):844-50 PMID: 2065038
  40. Normal plasma cholesterol in an 88-year-old man who eats 25 eggs a day. Mechanisms of adaptation.
    N Engl J Med. 1991 Mar 28;324(13):896-9 PMID: 1953841
  41. Compound heterozygosity for mutant hepatic lipase in familial hepatic lipase deficiency.
    Biochem Biophys Res Commun. 1991 Aug 30;179(1):78-84 PMID: 1883393
  42. Evidence that men with familial hypercholesterolemia can avoid early coronary death. An analysis of 77 gene carriers in four Utah pedigrees.
    JAMA. 1986 Jan 10;255(2):219-24 PMID: 3941501
  43. Apolipoprotein E polymorphism influences the serum cholesterol response to dietary intervention.
    Metabolism. 1991 Feb;40(2):217-21 PMID: 1988781
  44. Successful hyperlipemic pregnancy.
    JAMA. 1991 Apr 10;265(14):1858-60 PMID: 2005735
Article Info
Journal
Molecular and cellular biochemistry
Abbr.
Mol Cell Biochem
ISSN
0300-8177
DOI
10.1007/BF00231537
Published
1992-08-18
Pages
177-86
Language
English
Region
Netherlands
NLM ID
0364456
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00231537 View journal details
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