Expression of C4 on human lymphoid cells and possible involvement in immune recognition phenomena.

Science (New York, N.Y.) ·Vol. 193 ·No. 4247 ·1976-07-02 ·Pages 53-5

Ferrone S, Pellegrino MA, Cooper NR

Abstract

Immunochemical studies revealed the presence of the fourth component of complement (C4) on surfaces of human lymphoid cells. Antiserums to C4 inhibited the mixed lymphocyte reaction and the mitogenic response to phytohemagglutinin, suggesting a role for membrane-associated C4 in the afferent phase of immune recognition phenomena.

MeSH Terms

Antigen-Antibody Reactions Cell Line Complement C4 Complement System Proteins HLA Antigens Humans Immunity, Cellular Lymphocyte Activation Lymphocyte Culture Test, Mixed Lymphocytes/immunology Lymphoid Tissue/immunology Surface Properties

Chemicals

Complement C4 HLA Antigens Complement System Proteins

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Ferrone S

Pellegrino M A

Cooper N R

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.132701

Published

1976-07-02

Pages

53-5

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.132701 View journal details

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Expression of C4 on human lymphoid cells and possible involvement in immune recognition phenomena.

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