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PMID: 1331541 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Analysis of the UL36 open reading frame encoding the large tegument protein (ICP1/2) of herpes simplex virus type 1.

Journal of virology ·Vol. 66 ·No. 12 ·1992-12-00 ·Pages 7581-4

McNabb DS, Courtney RJ

Abstract

Using peptide antisera specific for regions within the N terminus and C terminus of the predicted UL36 gene product, immunoblotting experiments were performed to demonstrate definitively that ICP1/2 is encoded by the UL36 gene. These data also suggest that both the cell- and the virion-associated forms of ICP1/2 are colinear with the complete predicted amino acid sequence of the UL36 gene. Computer-assisted analyses of the predicted amino acid sequence of the UL36 gene revealed the presence of two putative leucine zipper-type motifs and a potential ATP-binding domain. The possible functions of these consensus domains will also be discussed.

MeSH Terms
Amino Acid Sequence Base Sequence Cell Line DNA-Binding Proteins/genetics Genes, Viral Humans Immune Sera Leucine Zippers/genetics Molecular Sequence Data Open Reading Frames Repetitive Sequences, Nucleic Acid Simplexvirus/genetics Viral Proteins/genetics Virion/genetics
Chemicals
DNA-Binding Proteins Immune Sera UL36 protein, Human herpesvirus 1 Viral Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
McNabb D S
Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, Shreveport 71130-3932.
Courtney R J
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.66.12.7581-7584.1992
Published
1992-12-00
Pages
7581-4
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC240474
Subset
IM
Grants
NCI NIH HHS · CA42460 · United States
External Links
PubMed source DOI: 10.1128/JVI.66.12.7581-7584.1992 PMC Full Text View journal details
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