Control of rat mammary-gland pyruvate dehydrogenase by insulin and prolactin.

The Biochemical journal ·Vol. 156 ·No. 2 ·1976-05-15 ·Pages 333-7

Field B, Coore HG

Abstract

Withdrawal of prolactin or of insulin from the circulation of lactating rats leads, within 3h, to increased inactivation by phosphorylation of mammary-gland pyruvate dehydrogenase. Prolactin may act by priming the tissue to respond directly to normal concentrations of circulating insulin and by this means be responsible for the increased activation of the enzyme during the course of normal lactation.

MeSH Terms

Animals Blood Glucose/analysis Bromocriptine/pharmacology Fatty Acids, Nonesterified/blood Female Hydrocortisone/pharmacology Insulin/blood,pharmacology,physiology Lactation/drug effects Mammary Glands, Animal/drug effects,enzymology Pregnancy Prolactin/blood,pharmacology,physiology Pyruvate Dehydrogenase Complex/analysis,metabolism Rats Streptozocin/pharmacology Time Factors

Chemicals

Blood Glucose Fatty Acids, Nonesterified Insulin Pyruvate Dehydrogenase Complex Bromocriptine Streptozocin Prolactin Hydrocortisone

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Field B

Coore H G

References (13)

13 references, click to expand

Effects of prolactin withdrawal on activity of pyruvate dehydrogenase of rat mammary gland.
Biochem Soc Trans. 1975;3(2):258-61 PMID: 1132556
COLORIMETRIC DETERMINATION OF FREE FATTY ACIDS IN BIOLOGICAL FLUIDS.
J Lipid Res. 1965 Jan;6:16-20 PMID: 14280466
Adaptive changes in satellite systems related to lipogenesis in rat and sheep mammary gland and in adipose tissue.
Eur J Biochem. 1973 Apr 2;34(1):188-98 PMID: 4144830
Alpha-keto acid dehydrogenase complexes. X. Regulation of the activity of the pyruvate dehydrogenase complex from beef kidney mitochondria by phosphorylation and dephosphorylation.
Proc Natl Acad Sci U S A. 1969 Jan;62(1):234-41 PMID: 4306045
Lipogenesis by acini from mammary gland of lactating rats.
J Biol Chem. 1974 Nov 25;249(22):7348-57 PMID: 4373465
Properties of pyruvate dehydrogenase of rat mammary tissue and its changes during pregnancy, lactation and weaning.
Biochem J. 1974 Jul;142(1):87-95 PMID: 4374188
Plasma glucose, progesterone and immunoreactive insulin levels in the lactating rat.
Horm Metab Res. 1974 Jul;6(4):297-300 PMID: 4415094
Uptake of chylomicron-triglyceride by perfused mammary tissue of lactating rats.
Am J Physiol. 1972 Dec;223(6):1418-23 PMID: 4674475
The stimulation by prolactin and growth hormone of fatty acid synthesis in explants from rat mammary glands.
J Endocrinol. 1973 May;57(2):265-76 PMID: 4735929
Changes in concentration of prolactin and adrenal corticosteroids in rat plasma during pregnancy and lactation.
J Endocrinol. 1973 Sep;58(3):675-6 PMID: 4743541
Effects of insulin on isolated rat mammary cell metabolism: glucose utilization and metabolite patterns.
Endocrinology. 1971 Nov;89(5):1263-9 PMID: 5107042
Regulation of adipose tissue pyruvate dehydrogenase by insulin and other hormones.
Biochem J. 1971 Nov;125(1):115-27 PMID: 5158898
Serum prolactin levels in rats during different reproductive states.
Endocrinology. 1970 Mar;86(3):506-10 PMID: 5410439

Article Info

Journal

The Biochemical journal

Abbr.

Biochem J

ISSN

0264-6021

DOI

10.1042/bj1560333

Published

1976-05-15

Pages

333-7

Language

English

Region

England

NLM ID

2984726R

PMCID

PMC1163753

Subset

External Links

PubMed source DOI: 10.1042/bj1560333 PMC Full Text View journal details

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Control of rat mammary-gland pyruvate dehydrogenase by insulin and prolactin.

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