Effects of Ca2+ antagonists and antiepileptics on tetrodotoxin-sensitive Ca(2+)-conducting channels in isolated rat hippocampal CA1 neurons.

Neuroscience letters ·Vol. 148 ·No. 1-2 ·1992-12-14 ·Pages 60-2

Takahashi K, Kameda H, Kataoka M, Ueno S, Akaike N

Abstract

All Ca2+ antagonists blocked tetrodotoxin-sensitive Ca2+ current (TTX-ICa) more potently than Na+ current (INa). Phenytoin and MK-801, at concentrations which had no effect on INa, could block TTX-ICa concentration-dependently. Valproic acid and phenobarbital had no effect on both TTX-ICa and INa. In particular, flunarizine and phenytoin have more potent inhibitory effects on TTX-ICa than other test drugs. These results suggest that the abnormal excess-excitation of TTX-sensitive Ca(2+)-conducting channels may be one of the trigger factors generating epilepsy.

MeSH Terms

Animals Anticonvulsants/pharmacology Calcium/pharmacology Calcium Channel Blockers/pharmacology Calcium Channels/drug effects,physiology Cells, Cultured Diltiazem/pharmacology Dizocilpine Maleate/pharmacology Dose-Response Relationship, Drug Flunarizine/pharmacology Hippocampus/physiology Kinetics Neurons/drug effects,physiology Nicardipine/pharmacology Phenobarbital/pharmacology Phenytoin/pharmacology Pyramidal Tracts/drug effects,physiology Rats Rats, Wistar Sodium/pharmacology Tetrodotoxin/pharmacology Valproic Acid/pharmacology Verapamil/pharmacology

Chemicals

Anticonvulsants Calcium Channel Blockers Calcium Channels Tetrodotoxin Valproic Acid Phenytoin Dizocilpine Maleate Sodium Verapamil Nicardipine Diltiazem Flunarizine Calcium Phenobarbital

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Takahashi K

Research Laboratories, Roussel Morishita Co., Ltd., Shiga, Japan.

Kameda H

Kataoka M

Ueno S

Akaike N

Article Info

Journal

Neuroscience letters

Abbr.

Neurosci Lett

ISSN

0304-3940

DOI

10.1016/0304-3940(92)90804-g

Published

1992-12-14

Pages

60-2

Language

English

Region

Ireland

NLM ID

7600130

Subset

External Links

PubMed source DOI: 10.1016/0304-3940(92)90804-g View journal details

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Effects of Ca2+ antagonists and antiepileptics on tetrodotoxin-sensitive Ca(2+)-conducting channels in isolated rat hippocampal CA1 neurons.

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