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PMID: 1346234 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Most gamma delta T cells develop normally in beta 2-microglobulin-deficient mice.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 89 ·No. 2 ·1992-01-15 ·Pages 653-7

Correa I, Bix M, Liao NS, Zijlstra M, Jaenisch R, Raulet D

Abstract

The specificity of T cells bearing gamma delta T-cell receptors (gamma delta+ T cells) is poorly characterized. Earlier studies suggest that like alpha beta+CD8+ T cells, some gamma delta+ T cells may recognize antigens associated with class I major histocompatibility complex molecules. alpha beta+CD8+ T cells are nearly absent in class I-deficient mice (mutant for beta 2-microglobulin), reflecting a requirement for intrathymic "positive selection" of these cells by class I molecules. Here, we examine whether the development of gamma delta+ T cells is altered in the beta 2-microglobulin mutant mice. We show that the cellularity, marker expression, repertoire, and functional competence of gamma delta+ T cells are not detectably deficient in beta 2-microglobulin mutant mice. We conclude that class I expression is unnecessary for the development of most gamma delta+ T cells.

MeSH Terms
Animals Antigens, Surface/analysis CD8 Antigens/analysis Epidermis/immunology Flow Cytometry Gene Rearrangement, T-Lymphocyte Genitalia/immunology Intestinal Mucosa/immunology Lymph Nodes/immunology Mice Mice, Mutant Strains Receptors, Antigen, T-Cell, gamma-delta/genetics,metabolism Spleen/immunology T-Lymphocyte Subsets/cytology Thy-1 Antigens Thymus Gland/immunology beta 2-Microglobulin/deficiency
Chemicals
Antigens, Surface CD8 Antigens Receptors, Antigen, T-Cell, gamma-delta Thy-1 Antigens beta 2-Microglobulin
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Correa I
Department of Molecular and Cell Biology, University of California, Berkeley 94720.
Bix M
Liao N S
Zijlstra M
Jaenisch R
Raulet D
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.89.2.653
Published
1992-01-15
Pages
653-7
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC48297
Subset
IM
Grants
NIAID NIH HHS · R01 AI31650 · United States
NCI NIH HHS · R35 CA44339 · United States
External Links
PubMed source DOI: 10.1073/pnas.89.2.653 PMC Full Text View journal details
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