Home LiteratureArticle Details
PMID: 1346517 Published · ppublish English Journal Article

Helicobacter pylori infection induces a decrease in immunoreactive-somatostatin concentrations of human stomach.

Digestive diseases and sciences ·Vol. 37 ·No. 3 ·1992-03-00 ·Pages 409-16

Kaneko H, Nakada K, Mitsuma T, Uchida K, Furusawa A, Maeda Y, Morise K

Abstract

Immunoreactive-somatostatin (ir-somatostatin) concentrations of the gastric mucosa and gastric juice with Helicobacter pylori infection were measured in the human stomach. One hundred seventy-one patients (106 males, 65 females; mean age, 52.0; range, 19-84 years) were registered. Gastric juice and mucosa were obtained with the usual endoscopy procedure. Somatostatin concentration was measured by radioimmunoassay. The ir-somatostatin concentrations in the H. pylori-negative group were significantly higher than in the positive group gastric mucosa, whereas its levels in gastric juice tended to decrease with H. pylori infection. There was an inverse correlation between luminal ammonia levels and ir-somatostatin concentrations of the gastric mucosa. On the other hand, ir-somatostatin concentrations of the gastric mucosa significantly decreased with chronic and active inflammatory change. This decrease was not correlated with the grade of active inflammation, which was in close relation to H. pylori infection, but with the grade of chronic inflammation. These results indicate that H. pylori may reduce ir-somatostatin concentrations of the human stomach and that its effect is partly mediated via luminal ammonia produced by H. pylori.

MeSH Terms
Adult Aged Aged, 80 and over Ammonia/analysis Female Gastric Acidity Determination Gastric Juice/metabolism Gastric Mucosa/metabolism Gastritis/metabolism Gastroscopy Helicobacter Infections/metabolism Humans Male Middle Aged Multivariate Analysis Radioimmunoassay Somatostatin/metabolism
Chemicals
Somatostatin Ammonia
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Kaneko H
Fourth Department of Internal Medicine, Aichi Medical University, Japan.
Nakada K
Mitsuma T
Uchida K
Furusawa A
Maeda Y
Morise K
References (31)
31 references, click to expand
  1. Effect of intraluminal pH on the release of somatostatin and gastrin into antral, bulbar and ileal pouches of conscious dogs.
    Acta Physiol Scand. 1980 Dec;110(4):391-400 PMID: 6112841
  2. Vagal release of somatostatin into the antral lumen of cats.
    Acta Physiol Scand. 1977 Jan;99(1):126-8 PMID: 14480
  3. Campylobacter pylori and recurrence of duodenal ulcers--a 12-month follow-up study.
    Lancet. 1987 Nov 14;2(8568):1109-11 PMID: 2890019
  4. Helicobacter pylori-associated exaggerated gastrin release in duodenal ulcer patients. The effect of bombesin infusion and urea ingestion.
    Gastroenterology. 1991 Jun;100(6):1571-5 PMID: 2019363
  5. Measurement of gut hormonal peptides in biopsies from human stomach and proximal small intestine.
    Gut. 1983 Feb;24(2):114-9 PMID: 6343197
  6. Somatostatin in mucosa of stomach and duodenum in gastroduodenal disease.
    Gastroenterology. 1978 Jul;75(1):13-9 PMID: 45575
  7. Campylobacter pylori and duodenal ulcers: the gastrin link.
    Lancet. 1989 May 27;1(8648):1167-8 PMID: 2566737
  8. Campylobacter pyloridis, urease, hydrogen ion back diffusion, and gastric ulcers.
    Lancet. 1986 Jul 5;2(8497):15-7 PMID: 2873317
  9. Relation of Campylobacter pyloridis to gastritis and peptic ulcer.
    J Infect Dis. 1986 Apr;153(4):664-9 PMID: 3950448
  10. Prospective double-blind trial of duodenal ulcer relapse after eradication of Campylobacter pylori.
    Lancet. 1988 Dec 24-31;2(8626-8627):1437-42 PMID: 2904568
  11. Chronic antral gastritis in duodenal ulcer. Natural history and treatment with prostaglandin E1.
    Gastroenterology. 1986 Nov;91(5):1095-101 PMID: 3093305
  12. [Studies on the measurements of somatostatin by radioimmunoassay (author's transl)].
    Nihon Naibunpi Gakkai Zasshi. 1977 Sep 20;53(9):1106-17 PMID: 923864
  13. Determination of submicro quantities of ammonia.
    Anal Biochem. 1970 Feb;33(2):335-40 PMID: 5439486
  14. Urea hydrolysis in patients with Campylobacter pyloridis infection.
    Lancet. 1986 Apr 26;1(8487):965-6 PMID: 2871253
  15. Pyloric Campylobacter infection and gastroduodenal disease.
    Med J Aust. 1985 Apr 15;142(8):439-44 PMID: 3982346
  16. Somatostatin cell processes as pathways for paracrine secretion.
    Science. 1979 Sep 28;205(4413):1393-5 PMID: 382360
  17. Somatostatin and the stomach: exocrine and endocrine aspects.
    Metabolism. 1978 Sep;27(9 Suppl 1):1309-15 PMID: 355784
  18. Regulation of gastric somatostatin secretion in the mouse by luminal acidity: a local feedback mechanism.
    Gastroenterology. 1988 Feb;94(2):317-22 PMID: 2891584
  19. Luminal gastric somatostatin-like immunoreactivity in response to various stimuli in man.
    Dig Dis Sci. 1986 Aug;31(8):833-9 PMID: 2873975
  20. Somatostatin and the gastrointestinal tract.
    Clin Gastroenterol. 1980 Sep;9(3):733-53 PMID: 6107192
  21. The histological diagnosis of chronic gastritis in fibreoptic gastroscope biopsy specimens.
    J Clin Pathol. 1972 Jan;25(1):1-11 PMID: 5015372
  22. Effect of increasing Helicobacter pylori ammonia production by urea infusion on plasma gastrin concentrations.
    Gut. 1991 Jan;32(1):21-4 PMID: 1991633
  23. Ablation of exaggerated meal-stimulated gastrin release in duodenal ulcer patients after clearance of Helicobacter (Campylobacter) pylori infection.
    Am J Gastroenterol. 1990 Apr;85(4):394-8 PMID: 2327380
  24. Gastrointestinal somatostatin: extraction and radioimmunoassay in different species.
    Gut. 1978 Jul;19(7):655-63 PMID: 680597
  25. Inappropriate hypergastrinaemia in asymptomatic healthy subjects infected with Helicobacter pylori.
    Gut. 1990 May;31(5):522-5 PMID: 2351302
  26. Distribution and characterisation of immunoreactive somatostatin in human gastrointestinal tract.
    Regul Pept. 1983 Sep;7(1):53-65 PMID: 6139847
  27. Cholecystokinin potently releases somatostatin from canine fundic mucosal cells in short-term culture.
    Am J Physiol. 1985 May;248(5 Pt 1):G569-73 PMID: 2859810
  28. Endogenous somatostatin and the gut.
    Gut. 1986 Apr;27(4):457-67 PMID: 2870009
  29. Ingestion of Campylobacter pyloridis causes gastritis and raised fasting gastric pH.
    Am J Gastroenterol. 1987 Mar;82(3):192-9 PMID: 3826027
  30. Attempt to fulfil Koch's postulates for pyloric Campylobacter.
    Med J Aust. 1985 Apr 15;142(8):436-9 PMID: 3982345
  31. Unidentified curved bacilli on gastric epithelium in active chronic gastritis.
    Lancet. 1983 Jun 4;1(8336):1273-5 PMID: 6134060
Article Info
Journal
Digestive diseases and sciences
Abbr.
Dig Dis Sci
ISSN
0163-2116
DOI
10.1007/BF01307736
Published
1992-03-00
Pages
409-16
Language
English
Region
United States
NLM ID
7902782
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01307736 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2