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PMID: 13491763 Published · ppublish English Journal Article

Studies on the pathogenesis of fever. IV. The site of action of leucocytic and circulating endogenous pyrogen.

The Journal of experimental medicine ·Vol. 107 ·No. 2 ·1958-02-01 ·Pages 291-303

KING MK, WOOD WB

Abstract

By means of a method designed to compare the febrile responses produced by intracarotid and intravenous injections, the endogenous pyrogen, which is contained in leucocytic exudates and is present in the serum of rabbits 2 hours after intravenous injections of typhoid vaccine, has been shown to act directly upon the thermoregulatory centers of the brain. In contrast, the exogenous bacterial pyrogen present in serum obtained 5 minutes after vaccine injections was found to act by a different and less direct mechanism. These observations add strong support to the original hypothesis that endogenous pyrogen, presumably derived from polymorphonuclear leucocytes, is an essential factor in the pathogenesis of endotoxin fever.

Keywords
FEVER/etiology and pathogenesis
MeSH Terms
Animals Brain Endotoxins Fever/etiology Injections, Intravenous Interleukin-1 Leukocytes Pyrogens Rabbits
Chemicals
Endotoxins Interleukin-1 Pyrogens leukocyte endogenous mediator
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
KING M K
WOOD W B
References (20)
20 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.107.2.291
Published
1958-02-01
Pages
291-303
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2136792
Subset
OM
External Links
PubMed source DOI: 10.1084/jem.107.2.291 PMC Full Text View journal details
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