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PMID: 1356934 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Protection against Vibrio cholerae El Tor infection by specific antibodies against mannose-binding hemagglutinin pili.

Infection and immunity ·Vol. 60 ·No. 11 ·1992-11-00 ·Pages 4961-4

Osek J, Svennerholm AM, Holmgren J

Abstract

Both specific polyclonal antiserum and monoclonal antibodies against mannose-binding hemagglutinin fimbriae of Vibrio cholerae (mannose-sensitive hemagglutinin [MSHA]) were shown to protect against experimental cholera caused by vibrios of the El Tor biotype in the infant mouse and in the rabbit intestinal loop models. MSHA-specific Fab immunoglobulin fragments were also protective. No protective effect was observed against challenge with V. cholerae O1 of the classical biotype. These results suggest that MSHA pili play an important role in the pathogenesis of cholera caused by the El Tor biotype of V. cholerae and that induction of intestinal anti-MSHA immunity may be a worthwhile additional objective in the development of oral cholera vaccines.

MeSH Terms
Animals Animals, Suckling Antibodies, Monoclonal/immunology Cholera/prevention & control Fimbriae, Bacterial/immunology Hemagglutinins/immunology Immunization, Passive Immunoglobulin Fab Fragments/immunology In Vitro Techniques Mannose/metabolism Mice Rabbits Vibrio cholerae/immunology
Chemicals
Antibodies, Monoclonal Hemagglutinins Immunoglobulin Fab Fragments Mannose
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Osek J
Department of Medical Microbiology and Immunology, University of Göteborg, Sweden.
Svennerholm A M
Holmgren J
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19 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.60.11.4961-4964.1992
Published
1992-11-00
Pages
4961-4
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC258256
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.60.11.4961-4964.1992 PMC Full Text View journal details
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