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PMID: 135771 Published · ppublish English Case Reports Journal Article

A case of small-cell Sézary's syndrome with null-cell features.

Journal of clinical pathology ·Vol. 29 ·No. 9 ·1976-09-00 ·Pages 848-51

Goldstone AH, Cawley JC, Roberts SO, Leventine A, Barker CR

Abstract

A case of the small-cell variant of Sézary's syndrome (SS) is reported in which the SS cells lacked the surface-marker characteristics of both T- and B-cells. In particular, the SS cells failed to form E-rosettes even with a sensitive technique using 2-amino-ethylisothiouronium bromide (AET)-treated sheep red blood cells. The significance of these findings is briefly considered in relation to the existing literature.

MeSH Terms
Aged B-Lymphocytes/immunology Dermatitis, Exfoliative/immunology Humans Immune Adherence Reaction Lymphatic Diseases/immunology Lymphocytes/ultrastructure Male Skin Neoplasms/immunology Syndrome T-Lymphocytes/immunology beta-Aminoethyl Isothiourea
Chemicals
beta-Aminoethyl Isothiourea
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Goldstone A H
Cawley J C
Roberts S O
Leventine A
Barker C R
References (7)
7 references, click to expand
  1. The Sézary syndrome lymphoid cell: abnormal surface properties and mitogen responsiveness.
    Br J Haematol. 1975 Dec;31(4):553-64 PMID: 147100
  2. Absence of B- and T-cell markers on acute lymphoblastic leukaemic cells and persistence of the T-cell marker on mitogen-transformed T-lymphocytes.
    Br J Haematol. 1974 Apr;26(4):615-25 PMID: 4136032
  3. B and T lymphocyte subpopulations in human peripheral blood.
    Int Arch Allergy Appl Immunol. 1974;46(4):525-38 PMID: 4206591
  4. An improved rosetting assay for detection of human T lymphocytes.
    J Immunol Methods. 1974 Jul;5(2):131-5 PMID: 4600315
  5. Thymus-derived rosette-forming cells in various human disease states: cancer, lymphoma, bacterial and viral infections, and other diseases.
    J Clin Invest. 1973 May;52(5):1026-32 PMID: 4540711
  6. Combined studies of complement receptor and surface immunoglobulin-bearing cells and sheep erythrocyte rosette-forming cells in normal and leukemic human lymphocytes.
    J Clin Invest. 1973 Feb;52(2):377-85 PMID: 4567307
  7. Cytogenetic, cytophotometric, and ultrastructural study of large cerebriform cells of the Sézary syndrome and description of a small-cell variant.
    J Natl Cancer Inst. 1973 May;50(5):1145-62 PMID: 4268230
Article Info
Journal
Journal of clinical pathology
Abbr.
J Clin Pathol
ISSN
0021-9746
Published
1976-09-00
Pages
848-51
Language
English
Region
England
NLM ID
0376601
PMCID
PMC476191
Subset
IM
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