Home LiteratureArticle Details
PMID: 136101 Published · ppublish English Comparative Study Journal Article

Thrombogenic activity of mouse and human tumors: effects on platelets, coagulation, and fibrinolysis, and possible significance for metastases.

Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology ·Vol. 86 ·No. 3 ·1976-08-30 ·Pages 263-77

Gasic GJ, Koch PA, Hsu B, Gasic TB, Niewiarowski S

Abstract

Twelve mouse tumors and 29 human malignancies were assayed in vitro for their capacity to aggregate platelets and induce release of radiolabelled serotonin, and for their ability to coagulate blood plasma and digest the fibrin clot. It was discovered that many human and mouse tumors can induce release of radiolabelled serotonin but that the quantitative relationships between this activity of tumors and their capacity to aggregate platelets was variable, permitting tumors to be classified into 3 different types. The procoagulant and fibrinolytic activity was also quite variable. Since no correlation was found between the 4 assayed tumor activities they appear to be independent, separate thrombogenic properties of tumors. Although the information gathered by this study is still fragmentary, some speculations can be made about the role of these activities in treatment of malignant tumors and in determing patterns of body distribution and control of metastases.

MeSH Terms
Animals Blood Coagulation Blood Platelets/metabolism Fibrinolysis Humans In Vitro Techniques Mice Neoplasm Metastasis/blood Neoplasms, Experimental Platelet Aggregation Serotonin/blood
Chemicals
Serotonin
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Gasic G J
Koch P A
Hsu B
Gasic T B
Niewiarowski S
References (32)
32 references, click to expand
  1. Clot forming and clot stabilizing enzymes from the mouse tumor YPC-1.
    Biochem Biophys Res Commun. 1966 Sep 8;24(5):776-81 PMID: 5970512
  2. Aspirin and tumour metastasis.
    Lancet. 1972 Dec 30;2(7792):1416-7 PMID: 4118703
  3. Disseminating effect of heparin on experimental tumour metastases.
    Pathol Eur. 1969;4(3):274-82 PMID: 5403818
  4. The role of blood platelets in experimental metastases.
    Br J Cancer. 1973 Nov;28(5):429-35 PMID: 4758369
  5. Some properties of the cancer coagulative factor.
    Ir J Med Sci. 1961 Mar;423:106-12 PMID: 13730098
  6. Antimetastatic effects associated with platelet reduction.
    Proc Natl Acad Sci U S A. 1968 Sep;61(1):46-52 PMID: 5246932
  7. An enzymatic function associated with transformation of fibroblasts by oncogenic viruses. II. Mammalian fibroblast cultures transformed by DNA and RNA tumor viruses.
    J Exp Med. 1973 Jan 1;137(1):112-26 PMID: 4347288
  8. Platelet-tumor-cell interactions in mice. The role of platelets in the spread of malignant disease.
    Int J Cancer. 1973 May;11(3):704-18 PMID: 4801854
  9. Thromboplastic and fibrinolytic properties of three transplantable rat tumours.
    Acta Chir Scand. 1970;136(5):365-8 PMID: 4325785
  10. Tumor fluid thromboplastin activity.
    Int J Cancer. 1968 Sep 15;3(5):677-82 PMID: 5724526
  11. Evidence for effects of heparin on cell surfaces influencing experimental metastases.
    Int J Cancer. 1970 Jan 15;5(1):72-84 PMID: 5414745
  12. The role of the vertebral venous system in the metastasis of cancer to the spinal column; experiments with tumor-cell suspensions in rats and rabbits.
    Cancer. 1951 May;4(3):610-8 PMID: 14839615
  13. Coagulative properties of cancers.
    Ir J Med Sci. 1958 Oct;394:474-9 PMID: 13586996
  14. The surface properties of cancer cells: a review.
    Cancer Res. 1962 Jun;22:525-48 PMID: 13858936
  15. A study of the mechanism by which anticoagulation with warfarin inhibits blood-borne metastases.
    Cancer Res. 1973 Jun;33(6):1217-24 PMID: 4718672
  16. Adenosine diphosphate effect on contractility of human muscle actomyosin: inhibition by ethanol and acetaldehyde.
    Science. 1975 Jun 27;188(4195):1319-20 PMID: 124949
  17. Some effects of fibrinogen degradation products (FDP) on blood platelets.
    Thromb Diath Haemorrh. 1966 May 15;15(3):413-9 PMID: 5989026
  18. Cancer procoagulant A: a factor X activating procoagulant from malignant tissue.
    Thromb Res. 1975 Feb;6(2):127-37 PMID: 234638
  19. Fibrinolysis and circulating malignant cells.
    Surg Gynecol Obstet. 1973 May;136(5):733-6 PMID: 4701904
  20. Fibrinolysis in human malignant tumours.
    Acta Chir Scand. 1973;139(3):219-23 PMID: 4698483
  21. Clotting factors and metastasis formation.
    Am J Roentgenol Radium Ther Nucl Med. 1971 Jan;111(1):42-7 PMID: 5540931
  22. Experimental studies of metastases. A review. I.
    Mo Med. 1968 Jan;65(1):36-8 PMID: 4866145
  23. Environment of the blood-borne tumor embolus adherent to vessel wall.
    J Med. 1973;4(3):150-77 PMID: 4589261
  24. An enzymatic function associated with transformation of fibroblasts by oncogenic viruses. I. Chick embryo fibroblast cultures transformed by avian RNA tumor viruses.
    J Exp Med. 1973 Jan 1;137(1):85-111 PMID: 4347290
  25. Purification and characterization of the protein component of tissue factor.
    Biochemistry. 1970 Dec 22;9(26):5100-5 PMID: 4098334
  26. The platelet as an inflammatory cell.
    Ann N Y Acad Sci. 1972 Oct 27;201:131-7 PMID: 4119234
  27. An autopsy study of some routes of dissemination of cancer of the breast.
    Br J Cancer. 1973 Apr;27(4):336-40 PMID: 4701705
  28. Fibrinolysis associated with oncogenic transformation. Requirement of plasminogen for correlated changes in cellular morphology, colony formation in agar, and cell migration.
    J Exp Med. 1973 Nov 1;138(5):1056-64 PMID: 4355423
  29. Patterns of metastases in adenocarcinomas of man. An autopsy study of 4,728 cases.
    J Med. 1975;6(1):1-14 PMID: 1056412
  30. Sequence of events in experimental metastases of Walker 256 tumor: light, immunofluorescent, and electron microscopic observations.
    J Natl Cancer Inst. 1971 Mar;46(3):493-504 PMID: 4100699
  31. A contractile protein model for cell adhesion.
    Nature. 1966 Oct 22;212(5060):365-9 PMID: 5970144
  32. EXPERIMENTAL STUDIES OF THE INTRAVASCULAR DISSEMINATION OF ASCITIC V2 CARCINOMA CELLS IN THE RABBIT, WITH SPECIAL REFERENCE TO FIBRINOGEN AND FIBRINOLYTIC AGENTS.
    Bull Schweiz Akad Med Wiss. 1964 May;20:92-121 PMID: 14145390
Article Info
Journal
Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology
Abbr.
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol
ISSN
0084-5353
DOI
10.1007/BF00286945
Published
1976-08-30
Pages
263-77
Language
English
Region
Germany
NLM ID
1276653
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00286945
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2