Phenylalanine hydroxylation cofactor in phenylketonuria.

Science (New York, N.Y.) ·Vol. 128 ·No. 3337 ·1958-12-12 ·Pages 1506-8

KAUFMAN S

Abstract

The enzymatic conversion of phenylalanine to tyrosine had previously been shown to require a nonprotein cofactor. It has now been demonstrated by direct assay that the cofactor is present in phenylketonuric liver samples. The lack of a functional phenylalanine hydroxylating system in phenylketonuria is not due to the absence of the cofactor.

Keywords

PHENYLALANINE/metabolism

MeSH Terms

Biological Assay Hydroxylation Phenylalanine/metabolism Phenylketonurias Tyrosine

Chemicals

Tyrosine Phenylalanine

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

KAUFMAN S

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.128.3337.1506

Published

1958-12-12

Pages

1506-8

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.128.3337.1506 View journal details

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