The cytotoxic action of immune gamma globulin and complement on Krebs ascites tumor cells. I. Ultrastructural studies.

The Journal of experimental medicine ·Vol. 109 ·No. 5 ·1959-05-01 ·Pages 505-10

GOLDBERG B, GREEN H

Abstract

Electron microscopic studies of Krebs ascites tumor cells treated in vitro with rabbit immune gamma globulin revealed a distinctive alteration in the structure of the cellular surface membrane. The subsequent addition of complement to this system severely damaged the cytoplasmic matrix, mitochondria, and endoplasmic reticulum. This sequence of events provides a structural basis for the cytotoxic action of antibody and complement.

Keywords

AGAMMAGLOBULINEMIA/effects COMPLEMENT NEOPLASMS/experimental

MeSH Terms

Agammaglobulinemia Animals Antibodies Ascites Complement System Proteins Neoplasms, Experimental gamma-Globulins

Chemicals

Antibodies gamma-Globulins Complement System Proteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

GOLDBERG B

GREEN H

References (10)

10 references, click to expand

Structural changes produced in Brown-Pearce carcinoma cells by means of a specific antibody and complement.
J Exp Med. 1953 Jan;97(1):145-62 PMID: 13022870
The nuclear envelope; its structure and relation to cytoplasmic membranes.
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Nutrition needs of mammalian cells in tissue culture.
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Electron microscope studies of ascites tumor cells.
Ann N Y Acad Sci. 1956 Mar 14;63(5):748-73 PMID: 13314433
The action of cytotoxic antisera on the HeLa strain of human carcinoma.
Cancer Res. 1956 May;16(4):306-12 PMID: 13316756
The action of anti-Ehrlich ascites tumor antibody.
Cancer Res. 1956 Sep;16(8):774-83 PMID: 13364903
The role of a natural antibody in the rejection of mouse tumor cells by the chick embryo.
J Exp Med. 1957 Jul 1;106(1):111-26 PMID: 13439119
The antigenic composition of mouse ascites tumour cells using in vitro and gel-diffusion techniques.
Br J Cancer. 1957 Jun;11(2):287-95 PMID: 13460153
The cross reactions of antisera prepared against four human cell strains in continuous tissue culture.
J Immunol. 1957 Aug;79(2):113-7 PMID: 13475816
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Ann N Y Acad Sci. 1957 Dec 16;69(4):773-94 PMID: 13488329

Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.109.5.505

Published

1959-05-01

Pages

505-10

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2136969

Subset

External Links

PubMed source DOI: 10.1084/jem.109.5.505 PMC Full Text View journal details

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The cytotoxic action of immune gamma globulin and complement on Krebs ascites tumor cells. I. Ultrastructural studies.

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