Combined drug treatment of tuberculosis. I. Prevention of emergence of mutant populations of tubercle bacilli resistant to both streptomycin and isoniazid in vitro.

The Journal of clinical investigation ·Vol. 38 ·No. 8 ·1959-08-00 ·Pages 1349-55

COHN ML, MIDDLEBROOK G, RUSSELL WF

Abstract

暂无摘要

Keywords

ISONIAZID/effects MYCOBACTERIUM TUBERCULOSIS/effect of drugs on STREPTOMYCIN/effects

MeSH Terms

Bacillus Biomedical Research Gram-Positive Bacteria Humans In Vitro Techniques Isoniazid/pharmacology Mycobacterium tuberculosis/drug effects Streptomycin/pharmacology Tuberculosis

Chemicals

Isoniazid Streptomycin

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

COHN M L

MIDDLEBROOK G

RUSSELL W F

References (9)

9 references, click to expand

Control study of comparative efficacy of isoniazid, streptomycin-isoniazid, and streptomycin; para-aminosalicylic acid in pulmonary tuberculosis therapy. IV. Report on forty-week observations on 583 patients with streptomycin susceptible infections.
Am Rev Tuberc. 1953 Aug;68(2):264-9 PMID: 13065694
Bactericidal activity of streptomycin and isoniazid against tubercle bacilli.
Br Med J. 1954 Jan 16;1(4854):130-2 PMID: 13106497
Studies on isoniazid and tubercle bacilli. I. The isolation of isoniazid-resistant mutants in vitro.
Am Rev Tuberc. 1954 Sep;70(3):465-75 PMID: 13189061
United States Public Health service cooperative investigation of antimicrobial therapy of tuberculosis, V. Report on thirty-two-week observations on combinations of isoniazid, streptomycin, and para-aminosalicylic acid.
Am Rev Tuberc. 1954 Sep;70(3):521-6 PMID: 13189069
Studies on isoniazid and tubercle bacilli. II. The growth requirements, catalase activities, and pathogenic properties of isoniazid-resistant mutants.
Am Rev Tuberc. 1954 Oct;70(4):641-64 PMID: 13197742
Studies on isoniazid and tubercle bacilli. III. The isolation, drug-susceptibility, and catalase-testing of tubercle bacilli from isoniazid-treated patients.
Am Rev Tuberc. 1954 Nov;70(5):852-72 PMID: 13207636
Studies on the stability of isoniazid.
Am Rev Tuberc. 1955 May;71(5):732-42 PMID: 14361983
Sterilization of tubercle bacilli by isonicotinic acid hydrazide and the incidence of variants resistant to the drug in vitro.
Am Rev Tuberc. 1952 Jun;65(6):765-7 PMID: 14924201
Origin of Bacterial Resistance to Antibiotics.
J Bacteriol. 1948 Jul;56(1):63-74 PMID: 16561548

Article Info

Journal

The Journal of clinical investigation

Abbr.

J Clin Invest

ISSN

0021-9738

DOI

10.1172/JCI103910

Published

1959-08-00

Pages

1349-55

Language

English

Region

United States

NLM ID

7802877

PMCID

PMC442089

Subset

External Links

PubMed source DOI: 10.1172/JCI103910 PMC Full Text View journal details

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Combined drug treatment of tuberculosis. I. Prevention of emergence of mutant populations of tubercle bacilli resistant to both streptomycin and isoniazid in vitro.

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