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PMID: 1369744 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The retinoblastoma protein and cell cycle regulation.

Trends in genetics : TIG ·Vol. 8 ·No. 5 ·1992-05-00 ·Pages 180-5

Hamel PA, Gallie BL, Phillips RA

Abstract

Although the precise function of the retinoblastoma gene product, p110RB1, remains unknown, recent data suggest that it plays a role in the control of cellular proliferation by regulating transcription of genes required for a cell to enter or stay in a quiescent or G0 state, or for progression through the G1 phase of the cell cycle. However, it is difficult to rationalize the expression of p110RB1 in a wide range of tissues with the fact that mutations in the RB1 gene initiate cancers in a limited number of tissues.

Related Genes
CLN1 CLN2 CLN3 CYCD1 CYL1 E2 PRAD1 RB1 c-fos c-myc far1
MeSH Terms
Alleles Animals Cell Cycle/genetics,physiology Cell Division Cell Transformation, Viral Child, Preschool Cyclins/genetics,physiology Eye Neoplasms/genetics Fungal Proteins/physiology Genes, Retinoblastoma Humans Infant Mice Models, Genetic Oncogene Proteins, Viral/metabolism Oncogenes Oncogenic Viruses/physiology Organ Specificity Retinoblastoma/genetics Retinoblastoma Protein/genetics,physiology Schizosaccharomyces/genetics,physiology Species Specificity Transcription Factors/metabolism
Chemicals
Cyclins Fungal Proteins Oncogene Proteins, Viral Retinoblastoma Protein Transcription Factors
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Hamel P A
Department of Medical Genetics, University of Toronto, Canada.
Gallie B L
Phillips R A
Article Info
Journal
Trends in genetics : TIG
Abbr.
Trends Genet
ISSN
0168-9525
DOI
10.1016/0168-9525(92)90221-o
Published
1992-05-00
Pages
180-5
Language
English
Region
England
NLM ID
8507085
Subset
IM
External Links
PubMed source DOI: 10.1016/0168-9525(92)90221-o View journal details
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