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PMID: 13702952 Published · ppublish English Journal Article

Studies on infection and immunity in experimental typhoid fever. III. Effect of prophylactic immunization.

The Journal of experimental medicine ·Vol. 114 ·1961-09-01 ·Pages 327-42

GAINES S, LANDY M, EDSALL G, MANDEL AD, TRAPANI RJ, BENENSON AS

Abstract

A study was made of the efficacy of various antityphoid immunizing agents in immunizing chimpanzees against typhoid fever produced by feeding viable S. typhosa. It was found that both acetone-killed and heat-killed, phenol-preserved typhoid vaccines were effective in protecting against infection induced with either homologous or heterologous strains of typhoid bacilli. Purified O antigen induced no discernible protection, but some immunity was afforded by the administration of purified Vi antigen.

Keywords
TYPHOID/immunology
MeSH Terms
Animals Antigens Humans Immunity Immunization O Antigens Pan troglodytes Salmonella typhi Typhoid Fever/immunology Typhoid-Paratyphoid Vaccines Vaccination
Chemicals
Antigens O Antigens Typhoid-Paratyphoid Vaccines
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
GAINES S
LANDY M
EDSALL G
MANDEL A D
TRAPANI R J
BENENSON A S
References (24)
24 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.114.3.327
Published
1961-09-01
Pages
327-42
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2137464
Subset
OM
External Links
PubMed source DOI: 10.1084/jem.114.3.327 PMC Full Text View journal details
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