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PMID: 137157 Published · ppublish English Journal Article

Axonal dwindling in early experimental diabetes. I. A study of cross sectioned nerves.

Diabetologia ·Vol. 12 ·No. 6 ·1976-12-00 ·Pages 539-46

Jakobsen J

Abstract

A diminution of the cross sectional area of myelinated fibres in the common peroneal nerve was observed in rats four weeks after the induction of diabetes with streptozotocin. Small fibres were affected more than larger ones and the axon reduction was twice that of the myelin sheath. The fibre diminution and the decreased axon/myelin ratio may explain the slowing of nerve conduction in experimental diabetes.

MeSH Terms
Animals Axons/pathology Biometry Diabetic Neuropathies/pathology,physiopathology Male Microscopy, Electron Myelin Sheath/pathology Nerve Fibers, Myelinated/pathology Neural Conduction Rats Streptozocin
Chemicals
Streptozocin
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Jakobsen J
References (15)
15 references, click to expand
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Article Info
Journal
Diabetologia
Abbr.
Diabetologia
ISSN
0012-186X
DOI
10.1007/BF01220629
Published
1976-12-00
Pages
539-46
Language
English
Region
Germany
NLM ID
0006777
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01220629 View journal details
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