Home LiteratureArticle Details
PMID: 137237 Published · ppublish English Journal Article

Effect of long-chain fatty acids and acyl-CoA on mitochondrial permeability, transport, and energy-coupling processes.

Journal of bioenergetics and biomembranes ·Vol. 8 ·No. 6 ·1976-12-00 ·Pages 293-311

Wojtczak L

Abstract

The following effects of fatty acids and acyl-CoA thioesters on energy metabolism of mitochondria can now be assumed: (1) Inhibition of adenine nucleotide translocation. This effect may increase the energy state of mitochondria respiring under state 3 conditions and decrease phosphorylation potential in the surrounding medium (the cytoplasm). (2) Increased permeability to monovalent cations. This may lead to a partial energy dissipation due to a futile recycling of K+ (or another cation), namely and energy-dependent uptake and a passive outflow. (3) True uncoupling due to increased permeability to protons. This effect probably occurs at high concentrations of fatty acids only. (4) Substrate effect. Fatty acids in the form of acyl-CoA are excellent respiratory substrates for mitochondria of most tissues. Their oxidation is coupled to the generation of high energy state of the mitochondrial membrane and, consequently, to ATP synthesis.

MeSH Terms
Adenosine Triphosphatases/metabolism Adenosine Triphosphate/metabolism Biological Transport, Active/drug effects Carboxylic Acids/metabolism Chlorides/metabolism Coenzyme A/analogs & derivatives,metabolism,pharmacology Fatty Acids/pharmacology Mitochondria/drug effects,metabolism Mitochondrial ADP, ATP Translocases/metabolism Models, Biological NADH, NADPH Oxidoreductases/metabolism Oxygen Consumption/drug effects Permeability Phosphates/metabolism Structure-Activity Relationship
Chemicals
Carboxylic Acids Chlorides Fatty Acids Phosphates Adenosine Triphosphate Mitochondrial ADP, ATP Translocases NADH, NADPH Oxidoreductases Adenosine Triphosphatases Coenzyme A
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Wojtczak L
References (74)
74 references, click to expand
  1. Influence of potassium and other alkali cations on respiration of mitochondria.
    J Biol Chem. 1952 May;197(2):547-56 PMID: 12981085
  2. Effect of surface active agents on the latent ATPase of mitochondria.
    Biochim Biophys Acta. 1956 Sep;21(3):458-66 PMID: 13363952
  3. Studies of fatty acid oxidation. 4. The effects of fatty acids on the oxidation of other metabolites.
    Can J Biochem Physiol. 1956 Nov;34(6):1211-25 PMID: 13374585
  4. EVIDENCE FOR THE ACTIVATION OF FATTY ACIDS IN LIVER MITOCHONDRIA BY HIGH-ENERGY INTERMEDIATES FOR OXIDATIVE PHOSPHORYLATION.
    Biochim Biophys Acta. 1965 Feb 1;98:8-18 PMID: 14290843
  5. Effect of detergents on ADP translocation in mitochondria.
    FEBS Lett. 1974 Mar 15;40(1):72-6 PMID: 4851623
  6. Inhibition by fatty acyl esters of adenine nucleotide translocation in rat-liver mitochondria.
    FEBS Lett. 1972 Jul 1;23(3):303-308 PMID: 11946639
  7. DEPENDENCE OF RESPIRATION ON PHOSPHATE AND PHOSPHATE ACCEPTOR IN SUBMITOCHONDRIAL SYSTEMS. I. DIGITONIN FRAGMENTS.
    Biochim Biophys Acta. 1963 Oct 8;78:12-26 PMID: 14098166
  8. COUPLING OF ENERGY TO MITOCHONDRIAL SWELLING.
    Biochim Biophys Acta. 1963 Nov 15;78:534-6 PMID: 14088785
  9. On the mechanism of fatty acid inhibition of mitochondrial metabolism.
    Biochemistry. 1966 Apr;5(4):1134-9 PMID: 5958190
  10. Site-specific inhibitors of mitochondrial nicotinamide-nucleotide transhydrogenase.
    Eur J Biochem. 1972 Dec 18;31(3):496-504 PMID: 4405493
  11. Inhibition of oleate of the binding and exchange of ATP by mitochondrial membranes.
    Biochim Biophys Acta. 1969;189(3):455-6 PMID: 5363981
  12. INDUCTION OF SWELLING OF LIVER MITOCHONDRIA BY FATTY ACIDS OF VARIOUS CHAIN LENGTH.
    Biochim Biophys Acta. 1963 Oct 22;70:596-8 PMID: 14085946
  13. The effect of ATP and carnitine on the endogenous respiration of mitochondria from brown adipose tissue.
    Experientia. 1968 May 15;24(5):431-2 PMID: 5674966
  14. The phosphorylation potential generated by respiring mitochondria.
    Biochim Biophys Acta. 1973 Apr 5;292(3):534-53 PMID: 4705444
  15. Effects of palmitoyl CoA on citrate and malate transport by rat liver mitochondria.
    Proc Natl Acad Sci U S A. 1972 Apr;69(4):1003-7 PMID: 4502928
  16. The inhibition of translocation of adenine nucleotides through mitochondrial membranes by oleate.
    Biochem Biophys Res Commun. 1967 Jul 10;28(1):76-81 PMID: 4227821
  17. Effect of fatty acids and acyl-CoA on the permeability of mitochondrial membranes to monovalent cations.
    FEBS Lett. 1974 Aug 15;44(1):25-30 PMID: 4851641
  18. The inhibition of phosphate entry into rat liver mitochondria by organic mercurials and by formaldehyde.
    Biochem J. 1968 Mar;107(1):121-3 PMID: 5642616
  19. The metabolic significance of anion transport in mitochondria.
    Biochim Biophys Acta. 1974 Dec 30;346(3-4):213-44 PMID: 4613381
  20. Ultrastructural bases for metabolically linked mechanical activity in mitochondria. II. Electron transport-linked ultrastructural transformations in mitochondria.
    J Cell Biol. 1968 May;37(2):345-69 PMID: 5656397
  21. An appraisal of the functional significance of the inhibitory effect of long chain acyl-CoAs on mitochondrial transports.
    FEBS Lett. 1974 Feb 15;39(2):133-8 PMID: 4152771
  22. Oxidative phosphorylation in mitochondria of the wax moth and some other insects.
    Acta Biochim Pol. 1968;15(1):15-29 PMID: 5656025
  23. The effect of long-chain fatty acids on orthophosphate-adenosine 5'-triphosphate exchange activity associated with oxidative phosphorylation.
    Biochim Biophys Acta. 1965 Aug 24;105(2):233-45 PMID: 4221368
  24. Intramitochondrial distribution of magnesium.
    Biochem Biophys Res Commun. 1971 Sep 17;44(6):1330-7 PMID: 5003689
  25. Formation and disappearance of an endogenous uncoupling factor during swelling and contraction of mitochondria.
    Biochim Biophys Acta. 1961 Aug 19;51:442-56 PMID: 14007889
  26. On the formation of acetoacetate by rat-liver mitochondria.
    Acta Biochim Pol. 1968;15(2):227-34 PMID: 5658078
  27. Effect of metal cations on the inhibition of adenine nucleotide translocation by acyl-CoA.
    FEBS Lett. 1975 Jan 15;50(1):74-8 PMID: 1109934
  28. The role of metal ions in the transport of substrates in mitochondria.
    FEBS Lett. 1973 Dec 15;38(1):91-5 PMID: 4772695
  29. Transport of adenine nucleotides in mitochondria from the brown adipose tissue.
    Eur J Biochem. 1973 May 2;34(3):506-12 PMID: 4715659
  30. Studies on the distribution of potassium in the rat liver cell and the mechanism of potassium accumulation.
    Biochim Biophys Acta. 1957 Mar;23(3):504-9 PMID: 13426159
  31. Phosphorylation coupled to acyl-coenzyme A dehydrogenase-linked oxidation of fatty acids by liver and heart mitochondria.
    Biochim Biophys Acta. 1972 Sep 20;275(3):298-301 PMID: 5070055
  32. DEPENDENCE OF RESPIRATION OF PHOSPHATE AND PHOSPHATE ACCEPTOR IN SUBMITOCHONDRIAL SYSTEMS. II. SONIC FRAGMENTS.
    Biochim Biophys Acta. 1963 Oct 8;78:27-44 PMID: 14098181
  33. Inhibition of the mitochondrial adenine nucleotide transport system by oleyl CoA.
    Arch Biochem Biophys. 1972 May;150(1):199-209 PMID: 4260396
  34. Uncoupling of oxidative phosphorylation and inhibition of ATP-Pi exchange by a substance from insect mitochondria.
    Biochim Biophys Acta. 1960 Apr 8;39:277-86 PMID: 13845602
  35. Differences between the ATP-ADP ratios in the mitochondrial matrix and in the extramitochondrial space.
    Eur J Biochem. 1972 Nov 7;30(3):434-40 PMID: 4674294
  36. Adenine nucleotide translocation of mitochondria. 1. Specificity and control.
    Eur J Biochem. 1968 Oct 17;6(1):66-79 PMID: 5725814
  37. The conformational basis of energy conservation in membrane systems. II. Correlation between conformational change and functional states.
    Proc Natl Acad Sci U S A. 1968 Mar;59(3):830-7 PMID: 5238663
  38. Adenine nucleotide translocation of mitochondria. Identification of carrier sites.
    Eur J Biochem. 1970 Oct;16(2):313-35 PMID: 4248602
  39. Mitochondrial permeability and ATPase activity.
    Can J Biochem. 1967 Jun;45(6):897-909 PMID: 4226791
  40. Physiologically-induced loose coupling of brown-adipose-tissue mitochondria correlated to endogenous fatty acids and adenosine phosphates.
    Eur J Biochem. 1972 Jan 31;25(1):75-83 PMID: 5023583
  41. An endogenous uncoupling and swelling agent in liver mitochondria and its enzymic formation.
    J Biol Chem. 1959 Sep;234:2459-64 PMID: 14415393
  42. Studies of fatty acid oxidation. 5. The effect of decanoic acid on oxidative phosphorylation.
    Can J Biochem Physiol. 1956 Nov;34(6):1227-32 PMID: 13374586
  43. Oxidative phosphorylation accompanying the beta-oxidation of carnitine-bound fatty acids.
    Acta Chem Scand. 1965;19(8):1995-7 PMID: 5858051
  44. Further studies on the potassium requirements of mitochondria.
    Biochim Biophys Acta. 1955 Dec;18(4):482-7 PMID: 13304029
  45. Inhibited respiration and ATPase activity of rat liver mitochondria under conditions of matrix condensation.
    FEBS Lett. 1972 Sep 1;25(1):61-64 PMID: 11946721
  46. Catalysis of an oxygen exchange reaction between long-chain fatty acids and water by rat-liver mitochondria.
    Biochim Biophys Acta. 1965 Aug 24;105(2):246-52 PMID: 5849817
  47. Induced active transport of ions in mitochondria.
    Proc Natl Acad Sci U S A. 1965 May;53(5):1076-83 PMID: 5222551
  48. Differences between the reactivity of endogenous and exogenous adenine nucleotides in mitochondria as studied at low temperature.
    Eur J Biochem. 1968 Mar;4(1):1-8 PMID: 5646147
  49. Reversible inhibition of adenine nucleotide translocation by long chain fatty acyl coenzyme A esters in liver mitochondria of diabetic and hibernating animals.
    J Biol Chem. 1972 Mar 10;247(5):1513-9 PMID: 4335002
  50. Uncoupling activity of long-chain fatty acids.
    Biochim Biophys Acta. 1962 Aug 27;62:509-18 PMID: 13871487
  51. GRAMICIDIN AND ION TRANSPORT IN ISOLATED LIVER MITOCHONDRIA.
    Biochem J. 1965 May;95:393-402 PMID: 14340090
  52. Inhibition of phosphoenolpyruvate transport via the tricarboxylate and adenine nucleotide carrier systems of rat liver mitochondria.
    Biochem Biophys Res Commun. 1973 Jul 17;53(2):659-65 PMID: 4716993
  53. Morphology of mitochondria in the coupled, uncoupled and recoupled states.
    Exp Cell Res. 1967 Apr;46(1):129-43 PMID: 6025275
  54. Configurational changes in isolated rat liver mitochondria as revealed by negative staining. II. Modifications caused by changes in respiratory states.
    J Ultrastruct Res. 1972 Aug;40(3):235-60 PMID: 4115215
  55. Brown adipose tissue mitochondria.
    Biochim Biophys Acta. 1975 Mar 31;416(1):53-103 PMID: 235330
  56. On the specificity of the inhibition of adenine nucleotide translocase by long chain acyl-coenzyme A esters.
    Biochim Biophys Acta. 1974 Oct 16;369(1):86-94 PMID: 4278702
  57. A spectrophotometric study of the spontaneous and microsome-induced swelling of rat-liver mitochondria.
    Biochim Biophys Acta. 1960 Mar 25;39:53-61 PMID: 13795264
  58. On the nature of endogenous substrate in rat-liver mitochondria.
    Biochim Biophys Acta. 1967 Sep 6;143(2):285-91 PMID: 4292886
  59. A MITOCHONDRIAL FACTOR PRODUCING "LOOSE-COUPLING" OF RESPIRATION.
    Proc Natl Acad Sci U S A. 1959 Jan;45(1):1-5 PMID: 16590346
  60. Brown-adipose-tissue mitochondria. The influence of albumin and nucleotides on passive ion permeabilities.
    Eur J Biochem. 1973 Sep 3;37(3):523-30 PMID: 4777251
  61. Regulation of pyruvate metabolim in rat-liver mitochondria by adenine nucleotides and fatty acids.
    Eur J Biochem. 1972 May;27(1):181-91 PMID: 5049053
  62. Regulation of pyruvate metabolism by the mitochondrial energy state: The effect of palmityl-coenzyme A.
    FEBS Lett. 1972 Dec 15;28(3):265-270 PMID: 11946873
  63. Ion transport in heart mitochondria. 8. The effect of ethylenediaminetertraacetate on monovalent ion uptake.
    Biochim Biophys Acta. 1968 Nov 26;162(4):487-99 PMID: 4973276
  64. Effect of fatty acids on pyruvate carboxylation in rat liver mitochondria.
    FEBS Lett. 1972 Dec 15;28(3):253-258 PMID: 11946871
  65. Regulation of metabolic transport in rat and guinea pig liver mitochondria by long chain fatty acyl coenzyme A esters.
    J Biol Chem. 1974 Aug 25;249(16):5269-74 PMID: 4854073
  66. Ketogenesis in rat-liver mitochondria: stimulation by palmityl-coenzyme A.
    FEBS Lett. 1972 Oct 1;26(1):117-22 PMID: 4636720
  67. The inhibition of adenine nucleotide translocase activity by oleoyl CoA and its reversal in rat liver mitochondria.
    Biochem Biophys Res Commun. 1971 May 7;43(3):557-63 PMID: 5563306
  68. Stimulation and inhibition of mitochondrial adenosine triphosphatase activity by oleate.
    Biochim Biophys Acta. 1962 Oct 8;64:21-9 PMID: 14014138
  69. TWO SYSTEMS FOR THE ACTIVATION OF FATTY ACIDS IN RAT-LIVER MITOCHONDRIA.
    Biochim Biophys Acta. 1965 Apr 5;98:442-4 PMID: 14320240
  70. The nature and mechanism of action of uncoupling agents present in mitochrome preparations.
    Biochim Biophys Acta. 1960 Apr 8;39:267-76 PMID: 14403959
  71. Effects of fatty acids on the 32P-adenosine triphosphate exchange reaction in rat liver mitochondria.
    Nature. 1960 Jun 25;186:1046-7 PMID: 13792136
  72. Reversible inhibition of mitochondrial adenosine diphosphate phosphorylation by long chain acyl coenzyme A esters.
    J Biol Chem. 1971 Jan 25;246(2):402-11 PMID: 4250745
  73. Mitochondrial from hamster brown-adipose tissue. Regulation of respiration in vitro by variations in volume of the matrix compartment.
    Eur J Biochem. 1972 Dec 18;31(3):526-33 PMID: 4650156
  74. Reduction of pyridine nucleotides induced by adenosine diphosphate in kidney mitochondria. The influence of sodium, magnesium, and inhibitors of oxidative phosphorylation.
    J Biol Chem. 1973 Nov 25;248(22):7682-7 PMID: 4147982
Article Info
Journal
Journal of bioenergetics and biomembranes
Abbr.
J Bioenerg Biomembr
ISSN
0145-479X
DOI
10.1007/BF00765158
Published
1976-12-00
Pages
293-311
Language
English
Region
United States
NLM ID
7701859
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00765158 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2