Selective localization of tetracycline in mitochondria of living cells.

Science (New York, N.Y.) ·Vol. 133 ·No. 3447 ·1961-01-20 ·Pages 196-7

DU BUY HG, SHOWACRE JL

Abstract

The property of tetracycline to induce fluorescence has been used to determine its localization in living cells. It was found that this antibiotic, as well as the related antibiotics oxytetracycline and chlorotetracycline, specifically combines with the mitochondria of living cells, either in tissue culture or in fresh preparations from various organs.

Keywords

MITOCHONDRIA/metabolism TETRACYCLINE/metabolism

MeSH Terms

Anti-Bacterial Agents Chlortetracycline Hepatocytes Humans Mitochondria/metabolism Oxytetracycline Tetracycline/metabolism

Chemicals

Anti-Bacterial Agents Tetracycline Chlortetracycline Oxytetracycline

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

DU BUY H G

SHOWACRE J L

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.133.3447.196

Published

1961-01-20

Pages

196-7

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.133.3447.196 View journal details

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